Biosensor Device and Related Method

• US 20170315084A1
• Filed: 07/10/2017
• Published: 11/02/2017
• Est. Priority Date: 11/08/2013
• Status: Active Grant

• Current Assignee: Taiwan Semiconductor Manufacturing Company Limited
• Original Assignee: Taiwan Semiconductor Manufacturing Company Limited
• Inventors: Huang, Jui-Cheng, Liu, Yi-Shao, Cheng, Chun-Wen, Chen, Tung-Tsun, Wen, Chin-Hua
• Granted Patent: US 10,746,693 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence
• CPC Class Codes: G01N 27/4145 specially adapted for biomolecules, e.g. gate electrode with immobilised receptors

Abstract

A device includes a biosensor, a sensing circuit electrically connected to the biosensor, a quantizer electrically connected to the sensing circuit, a digital filter electrically connected to the quantizer, a selective window electrically connected to the digital filter, and a decision unit electrically connected to the selective window.

Claims

1. A method comprising:

inputting biological material to a biosensor;

sensing a response of the biosensor to the biological material by a sensing circuit;

converting the response to a digital signal;

filtering the digital signal by a digital filter to generate a filtered signal; and

selecting bits of the filtered signal according to a start time to generate a selected signal.

2. The method of claim 1, further comprising:

determining a biological condition according to analysis of the selected signal; and

outputting an indication of the biological condition.

3. The method of claim 1, further comprising:

feeding back the selected signal to a tuning circuit.

4. The method of claim 3, further comprising:

tuning a biasing condition of the bio sensor according to the selected signal.

5. The method of claim 3, further comprising:

tuning a biasing condition of the sensing circuit according to the selected signal.

6. The method of claim 1, further comprising:

feeding back the filtered signal to a tuning circuit.

7. The method of claim 6, further comprising:

tuning a biasing condition of at least the biosensor or the sensing circuit according to the filtered signal.

8. The method of claim 1, wherein filtering the digital signal comprises selecting at least one of an order of the digital filter or a type of the digital filter.

9. A method comprising:

transmitting a first analog signal indicating a biological parameter to a sensor circuit;

converting the first analog signal to a second analog signal by the sensor circuit, wherein the second analog signal is a different type of signal than the first analog signal;

transmitting the second analog signal to a quantizer circuit;

converting the second analog signal to a first digital signal by the quantizer circuit;

transmitting the first digital signal to a digital filter circuit;

filtering the first digital signal by the digital filter circuit;

transmitting the filtered first digital signal to a selective window circuit;

selecting a signal portion of the filtered first digital signal by the selective window circuit, wherein the selecting of the signal portion is based on a time offset;

transmitting the signal portion to a decision circuit; and

outputting a decision signal based on the signal portion by the decision circuit.

10. The method of claim 9, wherein the first analog signal is a current and the second analog signal is a voltage.

11. The method of claim 9, further comprising:

receiving a start time signal by the selective window circuit, wherein the time offset is based on the start time signal.

12. The method of claim 11, wherein the start time signal comprises a rising edge signal.

13. The method of claim 11, wherein the start time signal indicates a duration of time.

14. The method of claim 9, wherein the converting the first analog signal to a second analog signal is based on a feedback signal received by the sensor circuit from a tuning circuit.

15. The method of claim 14, wherein the feedback signal is based on the filtered first digital signal.

16. The method of claim 14, wherein the feedback signal is based on the signal portion.

17. A method comprising:

sensing a biological material with a biosensor to generate a first output signal, the first output signal representing a first duration of time, wherein the biosensor operates at a first bio sensor condition;

converting the first output signal to a second output signal, wherein the conversion is based on a first conversion parameter;

quantizing the second output signal into a digital signal;

filtering the digital signal with a digital filter;

selecting a portion of the filtered digital signal representing a second duration of time that is smaller than the first duration of time; and

based on the selected portion of the filtered digital signal, adjusting the first biosensor condition to a second biosensor condition that is different than the first biosensor condition.

18. The method of claim 17, further comprising:

based on the selected portion of the filtered digital signal, outputting a signal representing a biological condition.

19. The method of claim 17, further comprising:

based on the selected portion of the filtered digital signal, adjusting the first conversion parameter to a second conversion parameter that is different than the first conversion parameter.

20. The method of claim 17, wherein the digital filter comprises a moving average filter.