SPECTROMETRIC SYSTEMS AND MECHANICAL METHODS FOR IMPROVED FOCUS LOCALIZATION OF TIME AND SPACE-VARYING MEASUREMENTS
First Claim
1. An apparatus for collection of optical data, the apparatus comprising:
- a source of light including at least one transmitter configured to emit a beam of first light at at least one corresponding wavelength along a first axis;
a device includinga first set of selectively and individually re-orientable reflecting elements disposed parallel to a first plane when each of said reflecting elements from the first set is in a first reference orientation;
a reflecting element from the first set configured to redirect the first light, received from said beam, towards a predetermined point,wherein the predetermined point is separated from both the first and second sets;
andan optical receiver disposed in optical communication with said device to receive second light, the second light being the first light that has been scattered at the predetermined point.
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Abstract
A system and method of dynamically localizing a measurement of parameter characterizing tissue sample with waves produced by spectrometric system at multiple wavelengths and detected at a fixed location of the detector of the system. The parameter is calculated based on impulse response of the sample, reference data representing characteristics of material components of the sample, and path lengths through the sample corresponding to different wavelengths. Dynamic localization is effectuated by considering different portions of a curve representing the determined parameter, and provides for the formation of a spatial map of distribution of the parameter across the sample. Additional measurement of impulse response at multiple detectors facilitates determination of change of the measured parameter across the sample as a function of time.
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Citations
34 Claims
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1. An apparatus for collection of optical data, the apparatus comprising:
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a source of light including at least one transmitter configured to emit a beam of first light at at least one corresponding wavelength along a first axis; a device including a first set of selectively and individually re-orientable reflecting elements disposed parallel to a first plane when each of said reflecting elements from the first set is in a first reference orientation; a reflecting element from the first set configured to redirect the first light, received from said beam, towards a predetermined point, wherein the predetermined point is separated from both the first and second sets; and an optical receiver disposed in optical communication with said device to receive second light, the second light being the first light that has been scattered at the predetermined point. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An apparatus for collection of optical data, the apparatus comprising:
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an optical detector; a source of light including at least one transmitter configured to emit a beam of first light at at least one corresponding wavelength along a first axis; a optical system containing an array of spatially-reorientable reflecting elements and configured to deliver the first light, emanating from the source of light, to the optical detector while scanning an object with the beam by reorienting first and second groups of said reflecting elements between first and second reference orientations, respectively; and a data-processing system in operable communication with the optical detector and configured to acquire an output produced by the optical detector in response being irradiated with said first light that has been scattered by the object, the data-processing system including a computer-readable processor and tangible, non-transitory storage medium containing program code thereon, wherein said program code, when loaded onto the processor, causes the processor to receive reference data representing an empirically-defined spectrally-dependent characteristic of the object; to determine an impulse response of the object, the impulse response being associated with emission of the beam of light by the source; and to determine, as a function of time, at least one of (i) a wavelength-dependent material parameter characterizing the object and (ii) a position-dependent parameter characterizing the object based on a determined impulse response and the reference data; wherein the object is positioned at an intermediate point along a direction of propagation of the beam between the first and second groups of the reflecting elements, the first group of reflecting elements receiving the beam from the source of light, the second group of reflecting elements redirecting the first light, that has been scattered by the object, towards the optical detector. - View Dependent Claims (17, 18, 19, 20, 21, 22)
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23. A method for collecting optical data, the method comprising:
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redirecting a beam of light, that has been received from an optical source, with a first spatially-reorientable reflecting element from an array of reflecting elements of an optical device, towards a first point of an object, wherein said beam of light has at least one wavelength; receiving first light from said beam, that has been scattered by the object, from a second point of the object with a second spatially-reorientable reflecting element from said array to redirect said first light towards an optical detector; and with a data-processing system including a computer-readable processor; acquiring an output generated by the optical detector in response to being irradiated with said first light, the output representing an optical property of the object determined along a path from said first reflecting element to said second reflecting element through the object, said path defined by a gradient of concentration of a material component in the object; receiving, with the data-processing unit of the system, reference data representing an empirically-defined spectrally-dependent characteristic of the object; determining an impulse response of the object, the impulse response being associated with emission of light from the optical source; and determining, as a function of time, at least one of (i) a wavelength-dependent material parameter characterizing the object and (ii) a position-dependent material parameter characterizing the object based on a determined impulse response and the reference data. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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Specification