Device and Method for Hemorrhage Detection and Guided Resuscitation and Applications of Same
First Claim
1. A non-invasive vascular analysis (NIVA) system, comprising:
- at least one sensor, configured to acquire, continuously for a time period from T0 to T2, vascular signals from at least one peripheral vein, artery or perfused tissue of a living subject in real time, wherein the time period is divided into a first time period from T0 to T1, and a second time period from T1 to T2; and
a processing device communicatively coupled to the at least one sensor, configured to receive the vascular signals transmitted from the at least one sensor, and perform a spectral analysis on the vascular signals, wherein the spectral analysis comprises the steps of;
processing the vascular signals acquired at the first time period to obtain a baseline peripheral vascular signal frequency spectrum;
obtaining a plurality of baseline peaks {BN−
1} on the baseline peripheral vascular signal frequency spectrum, wherein N is a positive integer, and the plurality of baseline peaks {BN−
1} respectively corresponds to a plurality of frequencies {F0, F1, . . . , FN}, such that BN−
1 is a function of FN−
1 satisfying BN−
1=BN−
1 (FN−
1), wherein FN is greater than FN−
1;
processing the vascular signals acquired at the second time period to obtain a peripheral vascular signal frequency spectrum;
obtaining a plurality of peaks {BN−
1} on the peripheral vascular pressure frequency spectrum, wherein the plurality of peaks {PN−
1} correspond to the plurality of frequencies{F0, F1, . . . , FN}, such that PN−
1 is a function of FN−
1 satisfying PN−
1=PN−
1 (FN−
1); and
determining at least one hemodynamic parameter of the living subject at the second time period by comparing amplitudes of the peaks {PN−
1} to those of the baseline peaks {BN−
1} respectively.
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Accused Products
Abstract
Aspects of the invention relates to systems and methods for detecting volume status, volume overload, dehydration, hemorrhage and real time assessment of resuscitation, as well as organ failure including but not limited cardiac, renal, and hepatic dysfunction, of a living subject using non-invasive vascular analysis (NIVA). In one embodiment, a non-invasive device, which includes at least one sensor, is used to acquire vascular signals from the living subject in real time. The vascular signals are sent to a controller, which processes the vascular signals to determine at least one hemodynamic parameter, such as the volume status of the living subject. In certain embodiments, the vascular signals are processed by a spectral fast Fourier transform (FFT) analysis to obtain the peripheral vascular signal frequency spectrum, and the volume status of the living subject may be determined by comparing amplitudes of the peaks of the peripheral vascular signal frequency spectrum.
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Citations
38 Claims
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1. A non-invasive vascular analysis (NIVA) system, comprising:
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at least one sensor, configured to acquire, continuously for a time period from T0 to T2, vascular signals from at least one peripheral vein, artery or perfused tissue of a living subject in real time, wherein the time period is divided into a first time period from T0 to T1, and a second time period from T1 to T2; and a processing device communicatively coupled to the at least one sensor, configured to receive the vascular signals transmitted from the at least one sensor, and perform a spectral analysis on the vascular signals, wherein the spectral analysis comprises the steps of; processing the vascular signals acquired at the first time period to obtain a baseline peripheral vascular signal frequency spectrum; obtaining a plurality of baseline peaks {BN−
1} on the baseline peripheral vascular signal frequency spectrum, wherein N is a positive integer, and the plurality of baseline peaks {BN−
1} respectively corresponds to a plurality of frequencies {F0, F1, . . . , FN}, such that BN−
1 is a function of FN−
1 satisfying BN−
1=BN−
1 (FN−
1), wherein FN is greater than FN−
1;processing the vascular signals acquired at the second time period to obtain a peripheral vascular signal frequency spectrum; obtaining a plurality of peaks {BN−
1} on the peripheral vascular pressure frequency spectrum, wherein the plurality of peaks {PN−
1} correspond to the plurality of frequencies{F0, F1, . . . , FN}, such that PN−
1 is a function of FN−
1 satisfying PN−
1=PN−
1 (FN−
1); anddetermining at least one hemodynamic parameter of the living subject at the second time period by comparing amplitudes of the peaks {PN−
1} to those of the baseline peaks {BN−
1} respectively. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 33)
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11. A non-invasive vascular analysis (NIVA) system, comprising:
a non-invasive device, comprising; at least one sensor, configured to acquire vascular signals from a living subject in real time; and a controller communicatively coupled to the at least one sensor, configured to receive the vascular signals transmitted from the at least one sensor, and process the vascular signals to determine at least one hemodynamic parameter of the living subject. - View Dependent Claims (36, 37, 38)
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12-25. -25. (canceled)
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26. A non-invasive method for detecting or monitoring intravascular volume status, volume overload, dehydration, hemorrhage, cardiac/renal/hepatic function, pulmonary embolism, vascular endothelial function, vascular compliance, and real time assessment of resuscitation of a living subject, comprising:
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acquiring, from at least one peripheral vein, artery or perfused tissue of the living subject using a non-invasive device, vascular signals in real time; and processing the acquired vascular signals to obtain a peripheral vascular pressure frequency spectrum to determine at least one hemodynamic parameter of the living subject. - View Dependent Claims (27, 28, 29, 30, 31, 32, 34, 35)
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Specification