METHOD OF PRODUCING TRANSDERMAL ABSORPTION SHEET
First Claim
1. A method of producing a transdermal absorption sheet comprising, in this order:
- a polymer solution filling step of filling needle-like recessed portions on a mold having the needle-like recessed portions arranged two-dimensionally with a polymer solution;
a polymer solution drying step of drying the polymer solution filling the needle-like recessed portions to form a polymer layer; and
a peeling-off step of peeling off the polymer layer from the mold,wherein in the polymer solution drying step, low rate drying conditions are set in a concentration range in which an average solid content concentration of the polymer solution is 70 wt % or more and 80 wt % or less in terms of weight percent, andwhen a constant drying rate of water is used as an index, in the concentration range in which the average solid content concentration of the polymer solution is 70 wt % or more and 80 wt % or less in terms of weight percent, the constant drying rate is set to be lower than a maximum value of a constant drying rate under drying conditions in a concentration range in which the average solid content concentration of the polymer solution is less than 70 wt % and more than 80 wt % in terms of weight percent.
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Accused Products
Abstract
A method of producing a transdermal absorption sheet includes: filling needle-like recessed portions on a mold having the needle-like recessed portions with a polymer solution; drying the filled polymer solution to form a polymer layer; and peeling off the polymer layer, wherein, in drying the polymer solution, low rate drying conditions are set in a concentration range in which an average solid content concentration of the polymer solution is 70 wt % to 80 wt %. When a constant drying rate of water is used as an index, in the concentration range in which the average solid content concentration of the polymer solution is 70 wt % to 80 wt %, and the constant drying rate is lower than a maximum value of a constant drying rate under a drying condition where the average solid content concentration of the polymer solution is less than 70 wt % and more than 80 wt %.
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Citations
10 Claims
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1. A method of producing a transdermal absorption sheet comprising, in this order:
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a polymer solution filling step of filling needle-like recessed portions on a mold having the needle-like recessed portions arranged two-dimensionally with a polymer solution; a polymer solution drying step of drying the polymer solution filling the needle-like recessed portions to form a polymer layer; and a peeling-off step of peeling off the polymer layer from the mold, wherein in the polymer solution drying step, low rate drying conditions are set in a concentration range in which an average solid content concentration of the polymer solution is 70 wt % or more and 80 wt % or less in terms of weight percent, and when a constant drying rate of water is used as an index, in the concentration range in which the average solid content concentration of the polymer solution is 70 wt % or more and 80 wt % or less in terms of weight percent, the constant drying rate is set to be lower than a maximum value of a constant drying rate under drying conditions in a concentration range in which the average solid content concentration of the polymer solution is less than 70 wt % and more than 80 wt % in terms of weight percent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification