MULTI-DOSE DRUG DELIVERY DEVICE

• US 20170340837A1
• Filed: 05/26/2017
• Published: 11/30/2017
• Est. Priority Date: 05/26/2016
• Status: Active Grant

• Current Assignee: Insulet Corporation
• Original Assignee: Insulet Corporation
• Inventors: Nazzaro, David, McLaughlin, Ian, Kozin, Simon, McCaffrey, Maureen, Mac, Jackie, Doudoumopoulus, Alexander, Patel, Bhavin
• Granted Patent: US 10,363,374 B2
• Time in Patent Office: Days
• CPC Class Codes: A61M 2005/2474 with movable piercing means, e.g. ampoule remains fixed or steady
• CPC Class Codes: A61M 2005/3142 Modular constructions, e.g. supplied in separate pieces to be assembled by end-user
• CPC Class Codes: A61M 2005/31518 designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/1454 spring-actuated, e.g. by a clockwork
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/28 Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
• CPC Class Codes: A61M 5/31531 Microsyringes, e.g. having piston bore diameter close or equal to needle shaft diameter
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
• CPC Class Codes: A61M 5/32 Needles; Details of needles pertaining to their connection with syringe or hub infusion needles A61M5/158; Accessories for bringing the needle into, or holding the needle on, the body A61M5/42, A61M5/46 take precedence; guide needles for catheters A61M25/065; Devices for protection of needles apparatus specially adapted for cleaning or sterilising needles A61M5/001
• CPC Class Codes: A61M 5/42 having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced

Abstract

A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.

Claims

1. A drug delivery device for delivering a liquid drug to a patient over two or more doses, comprising:

a drug container configured to store the liquid drug, a first end of the drug container sealed by a plunger;

a needle conduit coupled to the plunger;

a needle insertion component coupled to the needle conduit; and

a drive component coupled to the plunger, the drive component comprising a dosing wheel and a plurality of spheres.

2. The drug delivery device of claim 1, wherein the dosing wheel comprises a hub and a plurality of radially extending arms.

3. The drug delivery device of claim 2, wherein one or more of the plurality of radially extending arms are positioned between adjacent spheres of the plurality of spheres.

4. The drug delivery device of claim 3, wherein a rotation of the dosing wheel in a first direction advances the plurality of spheres toward the plunger.

5. The drug delivery device of claim 4, wherein the plurality of spheres are configured to apply a force to the plunger to move the plunger toward a second end of the drug container to expel the liquid drug out of the drug container through the needle conduit.

6. The drug delivery device of claim 5, wherein a predetermined amount of the rotation of the dosing wheel causes a predetermined amount of the liquid drug to expel from the drug container.

7. The drug delivery device of claim 6, wherein the dosing wheel is configured such that stopping the rotation of the dosing wheel stops the liquid drug from being expelled from the drug container and restarting the rotation of the dosing wheel restarts the liquid drug being expelled from the drug container.

8. The drug delivery device of claim 4, wherein the rotation of the dosing wheel is controllable by user input.

9. The drug delivery device of claim 4, further comprising a controller, wherein the rotation of the dosing wheel is controllable by the controller.

10. The drug delivery device of claim 4, wherein the drive component further comprises one or more compression springs.

11. The drug delivery device of claim 10, wherein the one or more compressions springs are configured to apply a force to the plurality of spheres to move the plunger toward the second end of the drug container.

12. The drug delivery device of claim 5, wherein the needle conduit is arranged to enable the liquid drug to be expelled from the drug container in a direction opposite to a direction of a movement of the plunger.

13. The drug delivery device of claim 1, wherein the drug container comprises an International Organization for Standardization (ISO) standardized cartridge.

14. The drug delivery device of claim 1, wherein the needle insertion component comprises a soft needle and a hard needle.

15. The drug delivery device of claim 14, wherein the needle conduit is coupled to the soft needle.

16. A method for delivering a liquid drug stored in a drug container of a drug delivery device to a user over two or more doses, comprising:

activating the drug delivery device;

accessing the user with a needle component of the drug delivery device;

coupling the liquid drug to a needle conduit, the needle conduit coupled to the needle component;

driving a plurality of spheres toward a plunger sealing a first end of the drug container; and

rotating a dosing wheel having one or more radially extending arms positioned between one or more spheres of the plurality of spheres to regulate a movement of the plurality of spheres toward the plunger to expel the liquid drug through the needle conduit for delivery to the user.

17. The method of claim 16, wherein rotating the dosing wheel comprises regulating the movement of the plurality of spheres toward a second end of the drug container.

18. The method of claim 16, further comprising coupling the liquid drug to the needle conduit through the plunger.

19. The method of claim 16, wherein driving further comprises driving the plurality of spheres with one or more compression drive springs.

20. The method of claim 16, wherein activating further comprises receiving a user input.