COMPOSITIONS COMPRISING BACTERIAL STRAINS
4 Assignments
0 Petitions
Accused Products
Abstract
The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.
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Citations
65 Claims
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1-35. -35. (canceled)
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36. A method of treating a condition mediated by the Th17 pathway in a subject, comprising:
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administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a bacterial strain, wherein said bacterial strain comprises a 16s rRNA sequence with at least 95% homology to the sequence shown in SEQ ID NO;
9;wherein said bacterial strain is live and viable; and wherein said administering is effective to reduce the level a one cytokine of the Th17 pathway in the subject relative to the level of said cytokine prior to the administering, thereby treating said condition. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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49. A method of treating a condition mediated by the Th17 pathway in a subject, comprising:
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administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising from about 1×
106 to about 1×
1011 colony forming units (CFU)/g of a bacterial strain of the species Parabacteroides distasonis;
wherein the administering of the pharmaceutical composition to the subject reduces a level of a cytokine of the Th17 pathway in the subject relative to the level of said cytokine prior to the administering;
thereby treating said condition. - View Dependent Claims (50, 51, 52, 53, 54, 55)
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56. A pharmaceutical composition that contains:
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a therapeutically effective amount of a single bacterial strain that comprises a 16s rRNA sequence with at least 95% homology to the sequence of SEQ ID NO;
9, wherein said bacterial strain is live and viable; anda pharmaceutically acceptable excipient, diluent, or carrier; wherein said bacterial strain is lyophilized. - View Dependent Claims (57, 58, 59, 60, 61, 62, 63, 64)
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65. A food product containing a single bacterial strain that comprises a polynucleotide sequence that is a 16s rRNA sequence with at least 99.9% homology to the polynucleotide of SEQ ID NO:
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Specification