METHOD AND SYSTEM FOR DRUG DELIVERY

• US 20170360089A1
• Filed: 08/30/2017
• Published: 12/21/2017
• Est. Priority Date: 12/22/2010
• Status: Active Grant

• Current Assignee: Syqe Medical Ltd.
• Original Assignee: Syqe Medical Ltd.
• Inventors: DAVIDSON, Perry, SCHORR, Aaron, HOLTZ, Arie, PONG, Will, SCHWARTZ, Binyamin
• Granted Patent: US 11,071,712 B2
• Time in Patent Office: Days
• CPC Class Codes: A24F 40/10 Devices using liquid inhalable precursors
• CPC Class Codes: A24F 40/20 Devices using solid inhalable precursors
• CPC Class Codes: A24F 40/485 Valves; Apertures
• CPC Class Codes: A24F 40/50 Control or monitoring
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/007 Pulmonary tract; Aromatherapy
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61M 11/041 using heaters
• CPC Class Codes: A61M 11/042 electrical
• CPC Class Codes: A61M 11/048 with a flame, e.g. using a burner
• CPC Class Codes: A61M 15/0003 with means for dispensing more than one drug
• CPC Class Codes: A61M 15/0016 located downstream of the dispenser, i.e. traversed by the product
• CPC Class Codes: A61M 15/002 with air flow regulating means
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/0051 the dosages being arranged on a tape, e.g. strips
• CPC Class Codes: A61M 15/0055 the used dosages being coiled
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/0066 with means for varying the dose size
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/0081 Locking means
• CPC Class Codes: A61M 15/0083 : Timers
• CPC Class Codes: A61M 2016/0021 : with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2016/0039 : in the inspiratory circuit
• CPC Class Codes: A61M 2202/062 : Desiccants
• CPC Class Codes: A61M 2205/12 : with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/13 : with means for the detection of operative contact with patient, e.g. lip sensor
• CPC Class Codes: A61M 2205/17 : with redundant control systems
• CPC Class Codes: A61M 2205/18 : with alarm
• CPC Class Codes: A61M 2205/276 : preventing unwanted use
• CPC Class Codes: A61M 2205/3306 : Optical measuring means
• CPC Class Codes: A61M 2205/3331 : Pressure; Flow
• CPC Class Codes: A61M 2205/3365 : Rotational speed
• CPC Class Codes: A61M 2205/3368 : Temperature
• CPC Class Codes: A61M 2205/3553 : remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3584 : using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/3592 : using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/3606 : cooled
• CPC Class Codes: A61M 2205/364 : by chemical reaction
• CPC Class Codes: A61M 2205/3653 : by Joule effect, i.e. electric resistance
• CPC Class Codes: A61M 2205/3673 : thermo-electric, e.g. Peltier effect, thermocouples, semi-conductors
• CPC Class Codes: A61M 2205/368 : by electromagnetic radiation, e.g. IR waves
• CPC Class Codes: A61M 2205/502 : User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/52 : with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/581 : by audible feedback
• CPC Class Codes: A61M 2205/583 : by visual feedback
• CPC Class Codes: A61M 2205/587 : Lighting arrangements
• CPC Class Codes: A61M 2205/60 : with identification means
• CPC Class Codes: A61M 2205/6009 : for matching patient with his treatment, e.g. to improve transfusion security
• CPC Class Codes: A61M 2205/6018 : providing set-up signals for the apparatus configuration
• CPC Class Codes: A61M 2205/6054 : Magnetic identification systems
• CPC Class Codes: A61M 2205/6063 : Optical identification systems
• CPC Class Codes: A61M 2205/6072 : Bar codes
• CPC Class Codes: A61M 2205/8206 : battery-operated
• CPC Class Codes: A61M 2207/00 : Methods of manufacture, assembly or production
• CPC Class Codes: A61M 2209/06 : Packaging for specific medical equipment
• CPC Class Codes: A61M 2209/10 : Equipment for cleaning
• CPC Class Codes: G16H 20/13 : delivered from dispensers

Abstract

There is provided in accordance with an exemplary embodiment of the invention, a device and a method for controlled extraction of at least one active substance from at least one type of plant matter by application of heat, the device comprising: a heating element adapted to apply heat to an area of the plant matter to extract the substance; and a mechanism adapted for moving the plant matter relative to the heating element. Optionally, the active substance is a restricted substance. There is also provided in accordance with an exemplary embodiment of the invention, a method of monitoring and controlling inhalation of a restricted substance. There is provided in accordance with an exemplary embodiment of the invention, a method of manufacturing a tape of plant matter comprising an active substance.

Claims

1. A drug dose structure comprising source material for delivery by vaporization, comprising:

a first air permeable layer;

a second air permeable layer;

at least one of said first and second layers comprising an electrically resistive material;

an air permeable source material layer comprising plant matter fitted between said first and second layers;

said first and second layers each formed with apertures having a size smaller than 700 μ

m.

2. The drug dose structure according to claim 1, wherein a thickness of said layer of plant matter is between 0.2 mm and 1 mm.

3. The drug dose structure according to claim 1, wherein said layer of plant matter comprises trichomes that are substantially unburst or unbroken.

4. The drug dose structure according to claim 1, wherein said apertures have a size smaller than a size of trichomes of said plant matter.

5. The drug dose structure according to claim 1, wherein at least one of said first and second layers is a support layer.

6. The drug dose structure according to claim 1, wherein both of said first and second layers comprise an electrically resistive material.

7. The drug dose structure according to claim 1, wherein said electrically resistive material is in the form of a wire mesh.

8. The drug dose structure according to claim 1, wherein said apertures are large enough to let gas escape small enough to contain residue of heated plant matter.

9. The drug dose structure according to claim 1, wherein said apertures are between 25 μ

m to 500 μ

m in size.

10. The drug dose structure according to claim 1, wherein said apertures are 50 μ

m or less in size.

11. The drug dose structure according to claim 1, wherein said apertures cover about 50% of a surface area of said layer of plant matter.

12. The drug dose structure according to claim 1, wherein said trichomes are about 100 μ

m.

13. The drug dose structure according to claim 1, wherein said layer of plant matter comprises cannabis.

14. The drug dose structure according to claim 1, wherein said layer of plant matter comprises tobacco.

15. The drug dose structure according to claim 1, wherein said layer of plant matter comprises between 5-20 mg of plant matter.

16. The drug dose structure according to claim 1, comprising an amount of plant matter from which at least one 2 mg treatment dose of active substance can be extracted.

17. The drug dose structure according to claim 1, wherein different areas of said layer of plant matter comprise different active substances.

18. The drug dose structure according to claim 1, wherein said layer of plant matter is manufactured by grinding and sieving plant material.

19. The drug dose structure according to claim 1, wherein a plurality of drug dose structures are stacked together, and wherein a difference in density of active substances between said plurality of drug dose structures is no more than 5%.

20. The drug dose structure according to claim 1, wherein said structure is provided by folding said electrically resistive material over said layer of plant matter to form said first and second support layers.

21. The drug dose structure according to claim 1, wherein said plant matter is compressed to a density between 10-30% which leaves enough air spaces to allow for vapors to escape.

22. The drug dose structure according to claim 1, wherein said plant matter is compressed to a density of about 20%.