APPARATUS AND METHOD TO FORM ENTRY BLEB FOR SUBRETINAL DELIVERY OF THERAPEUTIC AGENT
First Claim
1. An apparatus, comprising:
- (a) an injector, wherein the injector comprises;
(i) a body,(ii) a flexible cannula extending distally from the body,(iii) a flexible needle, wherein the needle is configured to translate relative to the cannula, and(iv) a sensor, wherein the sensor is operable to detect a position of the needle relative to the cannula;
(b) a first fluid conduit coupled with the needle;
(c) a second fluid line coupled with the needle; and
(d) a control module, wherein the control module is in communication with the sensor, wherein the control module is in communication with the first fluid conduit, wherein the control module is in communication with the second fluid conduit,wherein the control module is configured to provide delivery of a first fluid through the first conduit to the needle based on a signal from the sensor,wherein the control module is further configured to provide delivery of a second fluid through the second conduit to the needle.
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Abstract
An apparatus includes an injector, a first fluid conduit, a second fluid line, and a control module. The injector includes a body, a flexible cannula, a flexible needle, and a sensor. The needle is configured to translate relative to the cannula. The sensor is operable to detect a position of the needle relative to the cannula. The first and second fluid lines are coupled with the needle. The control module is in communication with the sensor, with the first fluid conduit, and with the second fluid conduit. The control module is configured to provide delivery of a first fluid through the first conduit to the needle based on a signal from the sensor. The control module is further configured to provide delivery of a second fluid through the second conduit to the needle.
21 Citations
20 Claims
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1. An apparatus, comprising:
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(a) an injector, wherein the injector comprises; (i) a body, (ii) a flexible cannula extending distally from the body, (iii) a flexible needle, wherein the needle is configured to translate relative to the cannula, and (iv) a sensor, wherein the sensor is operable to detect a position of the needle relative to the cannula; (b) a first fluid conduit coupled with the needle; (c) a second fluid line coupled with the needle; and (d) a control module, wherein the control module is in communication with the sensor, wherein the control module is in communication with the first fluid conduit, wherein the control module is in communication with the second fluid conduit, wherein the control module is configured to provide delivery of a first fluid through the first conduit to the needle based on a signal from the sensor, wherein the control module is further configured to provide delivery of a second fluid through the second conduit to the needle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. An apparatus, comprising:
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(a) an injector, wherein the injector comprises; (i) a body, (ii) a flexible cannula extending distally from the body, (iii) a flexible needle, wherein the needle is configured to translate relative to the cannula, and (iv) a sensor, wherein the sensor is operable to detect a position of the needle relative to the cannula; and (b) a control module, wherein the control module is in communication with the sensor, wherein the control module is configured to provide delivery of a combination of a first liquid and a gas to the needle based on a signal from the sensor, wherein the control module is further configured to provide delivery of a second fluid through the second conduit to the needle after delivering the combination of the first liquid and a gas to the needle.
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20. A method comprising:
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(a) inserting a flexible cannula into a sclerotomy of an eye of a patient, between a sclera and a choroid of the eye; (b) advancing a needle through the cannula while the cannula is disposed between the sclera and the choroid; (c) tracking advancement of the needle with the sensor; (d) automatically dispensing a leading bleb fluid through the needle based on data from the sensor, wherein the act of automatically dispensing a leading bleb fluid is performed while advancing the needle; and (e) injecting a therapeutic agent into a space between a retina and the choroid of the eye, via the advanced needle.
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Specification