Method and Device for Feedback Control of Neural Stimulation

• US 20170361101A1
• Filed: 12/11/2015
• Published: 12/21/2017
• Est. Priority Date: 12/11/2014
• Status: Active Grant

• Current Assignee: Saluda Medical Pty Ltd.
• Original Assignee: Saluda Medical Pty Ltd.
• Inventors: Single, Peter Scott Vallack
• Granted Patent: US 10,500,399 B2
• Time in Patent Office: Days
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36062 Spinal stimulation
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36139 with automatic adjustment

Abstract

A method of controlling a neural stimulus by use of feedback. The neural stimulus is applied to a neural pathway in order to give rise to an evoked action potential on the neural pathway. The stimulus is defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured. From the measured evoked response a feedback variable is derived. A feedback loop is completed by using the feedback variable to control the at least one stimulus parameter value. The feedback loop adaptively compensates for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway.

Claims

1. A method of controlling a neural stimulus, the method comprising:

applying the neural stimulus to a neural pathway in order to give rise to an evoked action potential on the neural pathway, the stimulus being defined by at least one stimulus parameter;

measuring a neural compound action potential response evoked by the stimulus, and deriving from the measured evoked response a feedback variable;

completing a feedback loop by using the feedback variable to control the at least one stimulus parameter value; and

adaptively compensating for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway.

2. The method of claim 1 wherein adaptively compensating for changes in the feedback loop comprises maintaining a corner frequency of the feedback loop at a desired value or within a desired range.

3. The method of claim 2 wherein the desired value or range of the corner frequency is selected to suitably attenuate low frequency noise such as heartbeat as well as high frequency noise such as electrical amplifier noise.

4. The method of claim 2 wherein the desired value or range of the corner frequency is selected to bias attenuation of heartbeat and noise while the recipient is in a more or most sensitive posture.

5. The method of claim 1 wherein the feedback loop is a first order feedback loop.

6. The method of claim 1 wherein the feedback loop is a second order feedback loop.

7. The method of claim 1 further comprising determining an estimate P′

of a slope P of a current ECAP growth curve.

8. The method of claim 7 wherein the estimation P′

is produced from an empirical relationship of stimulus current to measured ECAP amplitude.

9. The method of claim 7 wherein the estimation P′

is estimated as P′

=(V+K)/I, where V is ECAP amplitude, K is a constant or function which relates P to a stimulus threshold T, and I is stimulus current amplitude.

10. The method of claim 7 wherein the estimate P′

is introduced into the feedback loop to counteract the effect of P.

11. The method of claim 10 wherein an error signal of the feedback loop is scaled by 1/P′

.

12. The method of claim 1 wherein the feedback variable is an amplitude measure of the evoked compound action potential.

13. The method of claim 1 wherein the stimulus parameter is stimulus current.

14. The method of claim 1 wherein the set point of the feedback loop is configured so as to seek a constant value of ECAP amplitude.

15. The method of claim 1 wherein the set point of the feedback loop is configured so as to seek a target ECAP amplitude which changes over time as defined by a therapy map.

16. An implantable device for controllably applying a neural stimulus, the device comprising:

a plurality of electrodes including one or more nominal stimulus electrodes and one or more nominal sense electrodes;

a stimulus source for providing a stimulus to be delivered from the one or more stimulus electrodes to a neural pathway in order to give rise to an evoked action potential on the neural pathway;

measurement circuitry for recording a neural compound action potential signal sensed at the one or more sense electrodes; and

a control unit configured to;

control application of a neural stimulus as defined by at least one stimulus parameter;

measure via the measurement circuitry a neural compound action potential response evoked by the stimulus;

determine from the measured evoked response a feedback variable;

complete a feedback loop by using the feedback variable to control the at least one stimulus parameter value; and

adaptively compensate for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway.

17. A non-transitory computer readable medium for controllably applying a neural stimulus, comprising the following instructions for execution by one or more processors:

computer program code means for applying the neural stimulus to a neural pathway in order to give rise to an evoked action potential on the neural pathway, the stimulus being applied as defined by at least one stimulus parameter;

computer program code means for measuring a neural compound action potential response evoked by the stimulus and deriving from the measured evoked response a feedback variable;

computer program code means for completing a feedback loop by using the feedback variable to control the at least one stimulus parameter value; and

computer program code means for adaptively compensating for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway.