Embolic Containment

• US 20170367713A1
• Filed: 05/18/2017
• Published: 12/28/2017
• Est. Priority Date: 05/18/2016
• Status: Active Grant

• Current Assignee: Microvention Incorporated (Terumo Corporation)
• Original Assignee: Microvention Incorporated (Terumo Corporation)
• Inventors: Greene, JR., George R., Sepetka, Ivan, Lei, Cathy, Berenstein, Alejandro, Killer-Oberpfalzer, Monika
• Granted Patent: US 10,898,203 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 17/12031 complete occlusion
• CPC Class Codes: A61B 17/1204 temporary occlusion
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12118 for positioning in conjunction with a stent
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12177 comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/00867 shape memory effect
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2017/12063 electrolytically detachable
• CPC Class Codes: A61B 2017/12095 Threaded connection
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61F 2002/016 made from wire-like elements
• CPC Class Codes: A61F 2002/823 Stents, different from stent-grafts, adapted to cover an aneurysm
• CPC Class Codes: A61F 2230/0067 conical
• CPC Class Codes: A61F 2230/008 : paraboloidal
• CPC Class Codes: A61M 5/1407 : Infusion of two or more substances

Abstract

Devices, systems, and methods used to seal a treatment area to prevent embolic agents from migrating are described. The concept has particular benefit in allowing liquid embolic to be used with a variety of intravascular therapeutic applications, including for occluding aneurysms and arteriovenous malformations in the neurovasculature.

Claims

1. A device for preventing liquid embolic migration comprising:

a pusher;

an expandable structure delivered by the pusher, the expandable structure adopting a collapsed state when restrained in a catheter and an expanded state when freed from a catheter;

an expandable structure controller spanning both the pusher and the expandable structure;

wherein the expandable structure controller can be pushed or pulled independently of the pusher in order to manipulate the shape of the expandable structure so that the expandable structure can conform to the shape of a vascular treatment site to prevent passage of liquid embolic past the expandable structure.

2. The device of claim 1 wherein the expandable structure includes an inner mesh layer and an outer mesh layer and the inner mesh layer is less porous than the outer mesh layer in order to prevent passage of liquid embolic.

3. The device of claim 1 wherein the expandable structure includes a proximal tapered section, a cylindrical medial section, and a distal tapered section, where the distal tapered section prevents distal passage of liquid embolic.

4. The device of claim 3 wherein the distal tapered section includes a tubular band, and the expandable structure controller contacts the tubular band.

5. The device of claim 1 where the pusher contains a lumen and the expandable structure controller can be withdrawn through the lumen so that the lumen can be used to deliver liquid embolic to the vascular treatment site.

6. The device of claim 1 wherein the expandable structure includes a proximal segment and a distal segment, and pushing or pulling the expandable structure controller manipulates the shape of each of the proximal and distal segments.

7. The device of claim 6 wherein the proximal and distal segments of the expandable structure are separated by a constricting band.

8. A system for preventing liquid embolic migration comprising:

a liquid embolic delivery medium conveying liquid embolic from an area outside of the vasculature to a vascular treatment site within the vasculature;

a catheter used in conjunction with the liquid embolic delivery medium to place an expandable structure, the expandable structure adopting a collapsed state when restrained in the catheter and an expanded state when freed from the catheter;

wherein the expandable structure keeps liquid embolic within the vasculature treatment site by preventing passage of liquid embolic past the expandable structure.

9. The system of claim 8 wherein the catheter delivers the liquid embolic delivery medium.

10. The system of claim 8 wherein the vascular treatment site is an arteriovenous malformation, and the expandable structure is delivered through the venous system to the venous side of the arteriovenous malformation to prevent liquid embolic from entering the venous system.

11. The system of claim 8 wherein the expandable structure is a tight-knit mesh basket placed around the external surface of the liquid embolic delivery medium.

12. The system of claim 8 wherein the vascular treatment site is a sidewall aneurysm.

13. The system of claim 8 wherein the catheter and liquid embolic delivery medium are delivered through a common guide or access catheter.

14. The system of claim 8 wherein the expandable structure includes an inner layer and an outer layer, and the inner layer is less porous than the outer layer in order to prevent passage of liquid embolic.

15. The system of claim 8 wherein the expandable structure includes a distal tapered section which prevents distal passage of liquid embolic.

16. The system of claim 8 further comprising an expandable structure controller operable to manipulate the shape of the expandable structure.

17. The system of claim 8 wherein the vascular treatment site is a bifurcation aneurysm.

18. The system of claim 8 wherein the catheter delivers the liquid embolic delivery medium, and the liquid embolic delivery medium is connected to the expandable structure.

19. The system of claim 8 wherein the expandable structure includes a proximal mesh section and a distal mesh section separated by a constriction.

20. The system of claim 8 further comprising an expandable structure controller spanning both the liquid embolic delivery medium and the expandable structure.