NON-INVASIVE METHOD AND SYSTEM FOR ASSESSING SURVIVAL OF TRANSPLANTED FLAP

• US 20180008164A1
• Filed: 07/11/2016
• Published: 01/11/2018
• Est. Priority Date: 07/11/2016
• Status: Abandoned Application

• Current Assignee: CHI MEI Medical Center
• Original Assignee: CHI MEI Medical Center
• Inventors: WANG, JHI-JOUNG, LIN, BOR-SHYH, CHEN, CHUN-CHIA
• Application Number:
  US15/206,403
• Publication Number:
  US 20180008164A1
• Time in Patent Office: Days
• CPC Class Codes: A61B 2017/00969 used for transplantation
• CPC Class Codes: A61B 5/0531 Measuring skin impedance
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61B 5/4851 Prosthesis assessment or monitoring
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence
• CPC Class Codes: A61F 2/105 Skin implants, e.g. artificial skin

Abstract

A non-invasive method and system for assessing the survival of a transplanted flap involve the following steps. A control unit instructs a variable-frequency current generator circuit to generate a constant current at a fixed frequency and pass the constant current through a detection electrode. The detection electrode detects a bioelectrical impedance of the skin to which the flap has been transplanted, and the bioelectrical impedance of the skin is compared with a pre-defined threshold value. If the bioelectrical impedance of the skin exceeds the pre-defined threshold value, it is determined that an abnormal condition has occurred.

Claims

1. A non-invasive method for assessing survival of a transplanted flap, comprising the steps of:

A. generating a constant current at a fixed frequency, and passing the constant current through a detection electrode;

B. detecting with the detection electrode a bioelectrical impedance of a skin with a transplanted flap; and

C. comparing the bioelectrical impedance of the skin with the transplanted flap with a pre-defined threshold value, and if the bioelectrical impedance of the skin with the transplanted flap exceeds the pre-defined threshold value, determining that an abnormal condition has occurred.

2. The non-invasive method of claim 1, wherein the step C comprises subtracting a pre-transplantation bioelectrical impedance of the skin with the transplanted flap from a post-transplantation bioelectrical impedance of the skin with the transplanted flap to produce a difference, and if the difference exceeds a pre-defined threshold value, determining that the abnormal condition has occurred.

3. The non-invasive method of claim 1, wherein the step C comprises dividing a post-transplantation bioelectrical impedance of the skin with the transplanted flap that is detected with a current of a relatively low frequency by a post-transplantation bioelectrical impedance of the skin with the transplanted flap that is detected with a current of a relatively high frequency to produce a quotient, and if the quotient exceeds a pre-defined threshold value, determining that the abnormal condition has occurred.

4. The non-invasive method of claim 1, wherein the step C comprises standardizing a bioelectrical impedance of the skin with the transplanted flap, and if Im1(t)/Im1(0) or Im1(t)/Im2(0) is greater than a pre-defined threshold value, determining that the abnormal condition has occurred, wherein Im1(t) is a ratio of a post-transplantation bioelectrical impedance of the skin with the transplanted flap that is detected over time with a current of a relatively low frequency to a post-transplantation bioelectrical impedance of the skin with the transplanted flap that is detected over time with a current of a relatively high frequency, Im1(0) is a ratio of a pre-transplantation bioelectrical impedance of the skin with the transplanted flap that is detected with the current of the relatively low frequency to a pre-transplantation bioelectrical impedance of the skin with the transplanted flap that is detected with the current of the relatively high frequency, and Im2(0) is a ratio of a bioelectrical impedance of a normal skin that is detected with the current of the relatively low frequency to a bioelectrical impedance of the normal skin that is detected with the current of the relatively high frequency.

5. A non-invasive system for assessing survival of a transplanted flap by the non-invasive method of claim 1, comprising:

a control unit;

a variable-frequency current generator circuit electrically connected to the control unit;

a pair of said detection electrodes electrically connected to the variable-frequency current generator circuit; and

a voltage-reading circuit electrically connected to the detection electrodes and the control unit;

wherein the control unit instructs the variable-frequency current generator circuit to generate the fixed current, the voltage-reading circuit reads a potential difference between the detection electrodes, and the control unit calculates the bioelectrical impedance of the skin with the transplanted flap according to the constant current and the potential difference and compares the bioelectrical impedance with the pre-defined threshold value.

6. The non-invasive system of claim 5, further comprising a control input interface circuit electrically connected to the control unit to enable input of a desired frequency value.

7. The non-invasive system of claim 5, further comprising a wireless transmission circuit electrically connected to the control unit to output data obtained by the control unit.

8. The non-invasive system of claim 5, further comprising a display interface circuit electrically connected to the control unit to output data obtained by the control unit.

9. A non-invasive system for assessing survival of a transplanted flap by the non-invasive method of claim 2, comprising:

a control unit;

a variable-frequency current generator circuit electrically connected to the control unit;

a pair of said detection electrodes electrically connected to the variable-frequency current generator circuit; and

a voltage-reading circuit electrically connected to the detection electrodes and the control unit;

wherein the control unit instructs the variable-frequency current generator circuit to generate the fixed current, the voltage-reading circuit reads a potential difference between the detection electrodes, and the control unit calculates the bioelectrical impedance of the skin with the transplanted flap according to the constant current and the potential difference and compares the bioelectrical impedance with the pre-defined threshold value.

10. The non-invasive system of claim 9, further comprising a control input interface circuit electrically connected to the control unit to enable input of a desired frequency value.

11. The non-invasive system of claim 9, further comprising a wireless transmission circuit electrically connected to the control unit to output data obtained by the control unit.

12. The non-invasive system of claim 9, further comprising a display interface circuit electrically connected to the control unit to output data obtained by the control unit.