PARTICLE-CONTAINING MEMBRANE AND PARTICULATE ELECTRODE FOR ANALYTE SENSORS

• US 20180008173A1
• Filed: 09/21/2017
• Published: 01/11/2018
• Est. Priority Date: 09/19/2008
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Simpson, Peter C., Boock, Robert J., Wightlin, Matthew, Shults, Mark C.
• Granted Patent: US 10,028,684 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6848 Needles

Abstract

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

Claims

1-20. -20. (canceled)

21. A sensor for measuring an analyte concentration in a host, the sensor comprising:

an elongated body configured to be implanted at least in part in a host, wherein the elongated body comprises;

a substrate;

a first layer covering at least a portion of the substrate, wherein the first layer comprises a first conductive material, wherein a portion of the first layer comprises a first electroactive surface;

a second layer covering at least a portion of the first layer, wherein the second layer comprises an insulating material;

a third layer covering at least a portion of the second layer, wherein the third layer comprises a second conductive material, wherein a portion of the second layer comprises a second electroactive surface; and

a fourth layer covering at least a portion of the third layer, wherein the fourth layer comprise an insulating material;

wherein the first electroactive surface and the second electroactive surface are separated along a longitudinal axis of the elongated body by at least a portion of the fourth layer.

22. The sensor of claim 21, wherein the elongated body further comprises a fifth layer, wherein the fifth layer comprises a conductive material.

23. The sensor of claim 22, wherein the fifth layer comprises a silver-containing material.

24. The sensor of claim 21, wherein the conductive material of the first layer comprises a platinum-containing material, wherein the conductive material of the third layer comprises a platinum-containing material.

25. The sensor of claim 21, further comprising sensor electronics configured to process a signal received from the working electrode, wherein the sensor electronics are configured to apply a potential of from about 0.1V to about 0.8V to the working electrode.

26. The sensor of claim 25, wherein the sensor electronics are configured to apply a potential of from about 0.3V to about 0.7V to the working electrode.

27. The sensor of claim 25, wherein the sensor electronics are configured to apply a potential of from about 0.3V to about 0.5V to the working electrode.