ANALYTE SENSING BIOINTERFACE

• US 20180008176A1
• Filed: 09/21/2017
• Published: 01/11/2018
• Est. Priority Date: 04/15/2005
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Simpson, Peter C., Brauker, James H.
• Granted Patent: US 10,376,188 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.

Claims

1. An implantable continuous glucose sensor system, comprising:

a working electrode configured to measure a signal indicative of a glucose concentration;

a membrane disposed on the working electrode, wherein the membrane comprises a biointerface, wherein the biointerface comprises an electrically conductive material, wherein the biointerface is configured to promote a foreign body response that will not substantially attack or attempt to block sensing of glucose; and

electronics electrically coupled to the working electrode.

2. The sensor of claim 1, wherein the biointerface comprises an enzyme.

3. The sensor of claim 2, wherein the biointerface further comprises a resistance domain disposed over the enzyme.

4. The sensor of claim 1, wherein the biointerface further comprises a bioactive agent.

5. The sensor of claim 1, wherein the biointerface is substantially planar.