TECHNIQUES TO IMPROVE POLYURETHANE MEMBRANES FOR IMPLANTABLE GLUCOSE SENSORS
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Abstract
The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
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11 Claims
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1. (canceled)
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2. An implantable device for measuring an analyte m a biological fluid, comprising:
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an implantable sensor comprising an electrochemically reactive surface; and a membrane disposed over at least a portion of the electrochemically reactive surface, wherein the membrane comprises a domain comprising a first polymer and a second polymer, wherein the first polymer is polyurethane, wherein the second polymer comprises at least one hydrophilic component, wherein at least a portion of the hydrophilic component of the second polymer forms in the domain hydrophilic segments along which the analyte diffuses. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification