CELL PROCESSING SYSTEM AND METHOD WITH CENTRALIZED DATA MANAGEMENT, MONITORING AND/OR CONTROL

• US 20180015418A1
• Filed: 03/13/2017
• Published: 01/18/2018
• Est. Priority Date: 07/13/2016
• Status: Active Grant

• Current Assignee: Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Inventors: Binninger, Steven C., Olson, Bret M., Schlinker, Alaina, Wegener, Christopher J.
• Granted Patent: US 10,654,000 B2
• Time in Patent Office: Days
• CPC Class Codes: B01D 2315/02 Rotation or turning
• CPC Class Codes: B01D 2317/00 Membrane module arrangements within a plant or an apparatus
• CPC Class Codes: B01D 61/18 Apparatus therefor
• CPC Class Codes: B01D 61/22 Controlling or regulating
• CPC Class Codes: B01D 63/16 Rotary, reciprocated or vibrated modules
• CPC Class Codes: B04B 13/00 Control arrangements specially designed for centrifuges; Programme control of centrifuges control arrangements for feed, charge, or discharge B04B11/00
• CPC Class Codes: C12M 47/04 Cell isolation or sorting purging biological preparations of unwanted cells C12N5/0081, determining the presence or kind of microorganism C12Q1/04
• CPC Class Codes: G16H 10/40 for data related to laboratory analysis, e.g. patient specimen analysis
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

A network of cell processing systems including a plurality of cell processing instruments and a server computer. Each cell processing instrument includes a control circuit configured to operate the cell processing instrument according to a modifiable process parameter, a component of the cell processing instrument and a sensor configured to measure a characteristic of the component. The server computer is disposed remotely from the cell processing instruments, and is configured to transmit a request message for a value measured by the sensor, receive a response message based on the request message, and generate a notification message based on the response message.

Claims

1. A network of cell processing systems, comprising:

a plurality of cell processing systems, each cell processing system comprising;

a controller configured to operate the cell processing system according to a modifiable process parameter,

a component of the cell processing system; and

a sensor configured to measure a characteristic of the component; and

a server computer disposed remotely from the cell processing systems, wherein the server computer is configured to;

transmit a request message for a value measured by the sensor;

receive a response message based on the request message; and

generate a notification message based on the response message.

2. The network of cell processing systems of claim 1, wherein the component is a scale configured to weigh a fluid used by the cell processing system.

3. The network of cell processing systems of claim 2, wherein the characteristic is a weight value, wherein the server computer is configured to receive the weigh value in the response message, to compare the weight value to a predetermined tolerance, and to generate a notification message indicating the weight value is out of tolerance.

4. A system of cell processing systems with centralized control, the system comprising:

at least one cell processing system, the cell processing system comprising;

a processor to receive a biological fluid to be processed; and

a controller coupled to the processor, the controller configured to operate the processor according to a process comprising at least one process parameter;

a server in communication with the controller of the at least one cell processing system, the server configured to;

receive a process comprising at least one process parameter via an input; and

transmit the process to the at least one cell processing system, whereupon the controller of the at least one cell processing system operates the processor according to the at least one process parameter of the process.

5. The system with centralized control according to claim 4, wherein the server is configured to:

receive an identifier via an input coupled to the server;

determine if the identifier is associated with an administrator authorization; and

receive the process and transmit the process only if the identifier is associated with an administrator authorization.

6. The system with centralized control according to claim 4, wherein the server is configured to:

evaluate the process; and

transmit the process based on the evaluation of the at least one process parameter control.

7. The system with centralized control according to claim 6, wherein the server is configured to:

receive the at least one process parameter to be used during the process;

calculate at least one in-process condition based on the at least one process parameter;

compare the at least one calculated in-process condition with at least one in-process condition control; and

transmit the process only if the at least one calculated in-process condition matches the at least one in-process condition control.

8. The system with centralized control according to claim 7, wherein the server is configured to

calculate a plurality of in-process conditions corresponding to each step that defines the process;

compare a set of the plurality of calculated in-process conditions with a set of in-process condition controls; and

transmit the process only if the set of the plurality of calculated in-process conditions matches the set of in-process condition controls.

9. The system with centralized control according to claim 4, the processor including a separator configured to separate the biological fluid into at least two streams according to the process.

10. The system with centralized control according to claim 4, wherein the processor comprises a disposable fluid circuit and reusable hardware.

11. The system with centralized control according to claim 10, wherein the disposable fluid circuit comprises a spinning membrane separation device, one or more containers, and tubing connecting the spinning membrane and the one or more containers.

12. A system of cell processing systems with centralized control, the system comprising:

at least one cell processing system, the cell processing system comprising;

a processor to receive a biological fluid to be processed; and

a controller coupled to the processor, the controller configured to operate the processor according to a process comprising at least one process parameter;

a server in communication with the controller of the at least one cell processing system, the server configured to;

receive a process comprising at least one process parameter control associated with the at least one process parameter via an input; and

transmit the process to the at least one cell processing system, whereupon the controller of the at least one cell processing system operates the processor according to the at least one process parameter control.

13. The system with centralized control according to claim 12, wherein the server is configured to:

receive an identifier via an input coupled to the server;

determine if the identifier is associated with an administrator authorization; and

receive the process and transmit the process only if the identifier is associated with an administrator authorization.

14. The system with centralized control according to claim 12, the processor including a separator configured to separate the biological fluid into at least two streams according to the process.

15. The system with centralized control according to claim 12, wherein the processor comprises a disposable fluid circuit and reusable hardware.

16. The system with centralized control according to claim 15, wherein the disposable fluid circuit comprises a spinning membrane separation device, one or more containers, and tubing connecting the spinning membrane and the one or more containers