METHODS, COMPOSITIONS, AND MOLECULAR TARGETS THAT EXPLOIT SYNERGIES AND SYMBIOSES IN THE TERMITE GUT
First Claim
1. A method for controlling termite populations, the method comprising the steps of:
- administering a composition to a termite, the composition formulated to promote symbiont dysbiosis in a gut of the termite; and
exposing the termite to a pathogen;
wherein administering the composition increases the susceptibility of the termite to the pathogen.
1 Assignment
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Accused Products
Abstract
Methods and compositions for controlling termite populations by leveraging newly discovered mechanisms for symbiont- and host mediated anti-fungal defenses in the termite hind-gut. Such methods may include administering a composition to a termite, the composition formulated to promote protist dysbiosis in the gut of the termite, or silencing specific host or symbiont genes by RNA interference, and exposing the termite to a pathogen, where the composition increases the susceptibility of the termite to the pathogen. Compositions are also provided for the treatment of fungal infections, the composition comprising a medically effective amount of recombinant glycosyl hydrolase family 7 cellulase, as well as methods for utilizing the same.
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Citations
20 Claims
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1. A method for controlling termite populations, the method comprising the steps of:
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administering a composition to a termite, the composition formulated to promote symbiont dysbiosis in a gut of the termite; and exposing the termite to a pathogen; wherein administering the composition increases the susceptibility of the termite to the pathogen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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- 10. A method for treating of a fungal infection, the method comprising the step of administering a composition to a patient, the composition comprising a medically-effective amount of recombinant glycosyl hydrolase family 7 cellulase.
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13. A method for controlling termite populations comprising the steps of:
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manipulating expression of a targeted gene to compromise one or more defense mechanisms of a termite; and exposing the termite to at least one pathogen; wherein manipulating the expression of the targeted gene increases the susceptibility of the termite to the pathogen. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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Specification