METHOD OF PRODUCING TRANSDERMAL ABSORPTION SHEET

• US 20180029258A1
• Filed: 07/07/2017
• Published: 02/01/2018
• Est. Priority Date: 07/27/2016
• Status: Active Grant

• Current Assignee: Fujifilm Corporation (Fujifilm Holdings Corporation)
• Original Assignee: Fujifilm Corporation (Fujifilm Holdings Corporation)
• Inventors: OKANO, Keio, KATAGIRI, Yoshinobu
• Granted Patent: US 10,639,822 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 38/385 Serum albumin
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/0046 Solid microneedles
• CPC Class Codes: A61M 2037/0053 Methods for producing microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: B29C 31/041 using filling or dispensing heads placed in closed moulds or in contact with mould walls B29C45/27 takes precedence
• CPC Class Codes: B29C 31/044 with moving heads for distributing liquid or viscous material into the moulds
• CPC Class Codes: B29C 39/026 characterised by the shape of the surface
• CPC Class Codes: B29C 39/24 Feeding the material into the mould

Abstract

The method of producing a transdermal absorption sheet includes: preparing a mold having needle-like recessed portions and an angle of an inlet portion of 120° to 160°, and a liquid feeder including an opening portion and a lip land portion; filling the needle-like recessed portions with a solution by feeding the solution to the mold and moving the liquid feeder while bringing a rear end of a lip land portion on the secondary side of the liquid feeder into contact with the mold; and forming needle portions and a sheet portion using a polymer solution. In the filling of the solution, when the rear end of the lip land portion on the secondary side matches with a secondary side inlet of the needle-like recessed portion, the shortest distance from a primary side inlet of the needle-like recessed portion to a secondary side block is 220 μm or less.

Claims

1. A method of producing a transdermal absorption sheet comprising:

an apparatus preparing step of preparing a mold having needle-like recessed portions and having an angle of 120°

or more and 160°

or less inside the mold, the angle being formed between a flat portion of a surface and an inlet portion of the needle-like recessed portion, and a liquid feeding apparatus including a slit-shaped opening portion formed at a nozzle tip end portion and a lip land portion;

a filling step of filling the needle-like recessed portions with a solution by feeding the solution to the mold from the liquid feeding apparatus and moving the liquid feeding apparatus while, when a travelling direction of the liquid feeding apparatus is set to a primary side and a direction opposite to the travelling direction is set to a secondary side, bringing at least a rear end of the lip land portion on the secondary side into contact with the mold; and

a sheet portion forming step of forming needle portions and a sheet portion using a polymer solution,

wherein in the filling step, when the rear end of the lip land portion on the secondary side of the liquid feeding apparatus matches with a secondary side inlet of the needle-like recessed portion, the shortest length of a distance from a primary side inlet of the needle-like recessed portion to the lip land portion on the secondary side or a wall surface of a secondary side block of the opening portion of the liquid feeding apparatus is 220 μ

m or less.

2. The method of producing a transdermal absorption sheet according to claim 1,

wherein the lip land portion on the secondary side of the liquid feeding apparatus is parallel with a straight line connecting the primary side inlet and the secondary side inlet of the needle-like recessed portion.

3. The method of producing a transdermal absorption sheet according to claim 1,

wherein the lip land portion of the secondary side of the liquid feeding apparatus is inclined to a straight line connecting the primary side inlet and the secondary side inlet of the needle-like recessed portion.

4. The method of producing a transdermal absorption sheet according to claim 3,

wherein the lip land portion of the secondary side of the liquid feeding apparatus is inclined to the straight line connecting the primary side inlet and the secondary side inlet of the needle-like recessed portion in a direction in which the primary side is opened.

5. The method of producing a transdermal absorption sheet according to claim 2,

wherein a contact distance between the lip land portion of the secondary side of the liquid feeding apparatus and the mold in a travelling direction of the liquid feeding apparatus is 5,000 μ

m or less.

6. The method of producing a transdermal absorption sheet according to claim 2,

wherein a contact distance between the lip land portion of the secondary side of the liquid feeding apparatus and the mold in a travelling direction of the liquid feeding apparatus is equal to or shorter than the longest distance of the opening portion of the needle-like recessed portion in a moving direction of the liquid feeding apparatus.

7. The method of producing a transdermal absorption sheet according to claim 1,

wherein the lip land portion of the primary side of the liquid feeding apparatus is not in contact with the mold.

8. The method of producing a transdermal absorption sheet according to claim 7,

wherein the shortest length of a distance between the lip land portion of the primary side of the liquid feeding apparatus and the surface of the mold is 500 μ

m or less.

9. The method of producing a transdermal absorption sheet according to claim 7,

wherein the shortest length of the distance between the lip land portion of the primary side of the liquid feeding apparatus and the surface of the mold is 100 μ

m or more.

10. The method of producing a transdermal absorption sheet according to claim 1,

wherein a surface of the lip land portion of the primary side of the liquid feeding apparatus is formed of a material which is more hydrophobic than the surface of the mold.

11. The method of producing a transdermal absorption sheet according to claim 1,

wherein the surface of the lip land portion of the secondary side of the liquid feeding apparatus is formed of a material which is more hydrophilic than the surface of lip land portion of the primary side.

12. The method of producing a transdermal absorption sheet according to claim 1,

wherein the opening portion of the liquid feeding apparatus has a notch portion which widens the opening portion on the primary side.

13. The method of producing a transdermal absorption sheet according to claim 1,

wherein a flat portion is provided between the needle-like recessed portions of the mold, and the shortest distance between the needle-like recessed portions is 0.1 mm or more.