PHARMACEUTICAL PREPARATION OF CARBOHYDRATES FOR THERAPEUTIC USE
First Claim
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1. A composition comprising:
- a lipid particle; and
an endogenous carbohydrate encapsulated in the lipid particle,wherein the lipid particle comprises a molecule capable of minimizing degradation of the lipid particle, enhancing retention of the lipid particle, and/or making the lipid particle immunotolerant when administered to a subject in need thereof.
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Abstract
The disclosure provides methods for preparation of carbohydrate replacement therapies (CRT) that include nanocarriers of carbohydrates and glycolipids for pharmaceutical delivery to cell interior, endoplasmic reticulum, and Golgi for treating CDG type I and CDG type II diseases as well as other metabolic disorders.
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Citations
20 Claims
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1. A composition comprising:
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a lipid particle; and an endogenous carbohydrate encapsulated in the lipid particle, wherein the lipid particle comprises a molecule capable of minimizing degradation of the lipid particle, enhancing retention of the lipid particle, and/or making the lipid particle immunotolerant when administered to a subject in need thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 13, 14, 15, 16, 17, 18, 19, 20)
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12. A composition comprising:
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a liposome; and mannose-1-phosphate encapsulated in the liposome, wherein the liposome comprises cholesterol and phosphatidylethanolamine (PE) attached to polyethylene glycol (PEG).
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Specification