SYRINGE

• US 20180056003A1
• Filed: 09/01/2017
• Published: 03/01/2018
• Est. Priority Date: 09/17/2010
• Status: Active Grant

• Current Assignee: Daicel Corporation
• Original Assignee: Daicel Corporation
• Inventors: Oda, Shingo
• Granted Patent: US 10,569,021 B2
• Time in Patent Office: Days
• CPC Class Codes: A61M 5/2046 Media being expelled from injector by gas generation, e.g. explosive charge
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion

Abstract

It is possible to feed an injection objective substance to a depth of a skin structure of an objective living body without using any injection needle. A syringe having no injection needle comprises an enclosing unit which encloses the injection objective substance, a pressurizing unit which pressurizes the injection objective substance enclosed in the enclosing unit, and a flow passage unit which defines a flow passage so that the injection objective substance, which is pressurized by the pressurizing unit, is allowed to inject to an injection target area. The pressurizing unit has a first pressurizing mode in which a pressure applied to the injection objective substance in the pressurizing unit is raised to a first peak pressure in order to form a penetrating passage in the injection target area, and then the pressure applied to the injection objective substance is lowered to a waiting pressure, and a second pressurizing mode in which the injection objective substance having the waiting pressure is pressurized so that the pressure applied to the injection objective substance is raised to a second peak pressure to inject a predetermined injection amount of the injection objective substance.

Claims

1. A syringe for injecting an injection objective substance into an injection target area of a living body without using any injection needle, the syringe comprising:

an enclosing unit which encloses the injection objective substance;

a pressurizing unit which pressurizes the injection objective substance enclosed in the enclosing unit; and

a flow passage unit which defines a flow passage so that the injection objective substance, which is pressurized by the pressurizing unit, is allowed to inject to the injection target area,

wherein the pressurizing unit has two pressurizing modes including;

a first pressurizing mode in which a pressure applied to the injection objective substance in the pressurizing unit is raised to a first peak pressure in order to allow the injection objective substance to penetrate through a surface of the injection target area, and then the pressure applied to the injection objective substance is lowered to a waiting pressure; and

a second pressurizing mode in which the injection objective substance having the waiting pressure is pressurized so that the pressure applied to the injection objective substance is raised to a second peak pressure to inject a predetermined injection amount of the injection objective substance,

wherein a rate of the waiting pressure to the first peak pressure in the first pressurizing mode is not more than 50%.

2. The syringe according to claim 1, wherein the rate of the waiting pressure to the first peak pressure is 40% to 50%.

3. The syringe according to claim 1, wherein the pressurizing unit comprises:

an ignition device including an ignition charge that exhibits such a characteristic that a plasma having a high temperature and a high pressure is generated during a combustion immediately after the ignition, but a generated pressure is suddenly lowered because of no gas component to be contained when an ordinary temperature is given and a combustion product is condensed; and

a combustion chamber into which the combustion product produced by combustion of the ignition charge is allowed to flow and which accommodates a gas generating agent that is to be combusted by the combustion product to produce a predetermined gas,

wherein the waiting pressure is a pressure applied to the injection objective substance when the pressure generated by the combustion of the ignition charge is lowered because of no gas component to be contained when the combustion product is condensed.

4. The syringe according to claim 1, wherein an erosion in the injection depth direction at the inside of the injection target area is mitigated, when the pressure applied to the injection objective substance is the waiting pressure.

5. The syringe according to claim 1, wherein a rate of pressure increase, which is provided from the waiting pressure to arrival at the second peak pressure in the second pressurizing mode, is lower than a rate of pressure increase which is provided from start of pressurization to arrival at the first peak pressure in the first pressurizing mode.

6. The syringe according to claim 1, wherein an amount of the injection objective substance in the second pressurizing mode is larger than an amount of the injection objective substance in the first pressurizing mode.

7. The syringe according to claim 3, wherein the pressurizing unit is characterized in that the pressurizing unit uses an increase in pressure generated by the combustion of the ignition charge in the ignition device as a pressurization transition until arrival at the first peak pressure in the first pressurizing mode, and an increase in pressure brought about by the predetermined gas produced by the gas generating agent as a pressurization transition until arrival at the second peak pressure in the second pressurizing mode.

8. The syringe according to claim 7, wherein:

a combustion completion time of the ignition charge comes earlier than a combustion completion time of the gas generating agent; and

a velocity of production of the gas from the gas generating agent is increased at a stage at which the combustion of the ignition charge is completed and the pressure applied to the injection objective substance is decreased from the first peak pressure to the waiting pressure.

9. The syringe according to claim 7, wherein the ignition charge is any one of explosive charges of an explosive charge containing zirconium and potassium perchlorate, an explosive charge containing titanium hydride and potassium perchlorate, an explosive charge containing titanium and potassium perchlorate, an explosive charge containing aluminum and potassium perchlorate, an explosive charge containing aluminum and bismuth oxide, an explosive charge containing aluminum and molybdenum oxide, an explosive charge containing aluminum and copper oxide, and an explosive charge containing aluminum and iron oxide, or an explosive charge composed of a combination of a plurality of the foregoing explosive charges.