LEADLESS NEUROMODULATION OF THE ADRENAL GLAND

• US 20180056071A1
• Filed: 08/22/2017
• Published: 03/01/2018
• Est. Priority Date: 08/23/2016
• Status: Abandoned Application

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Swanson, Lynne E., Clark, Bryan A., Werner, Dennis B., Stoffregen, William C., Govea, Michael X., Brill, Natalie A.
• Application Number:
  US15/683,773
• Publication Number:
  US 20180056071A1
• Time in Patent Office: Days
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36121 Production of neurotransmitters; Modulation of genes expression
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

Aspects of the present disclosure are directed towards apparatuses, systems, and methods that include at least one implantable medical device. The implantable medical device may include a leadless body portion configured to engage an adrenal gland of a patient and at least one electrode, arranged within the leadless body portion, configured to deliver stimulation energy to modulate catecholamine release from chromaffin cells within the adrenal gland.

Claims

1. An implantable medical device comprising:

a leadless body portion;

a mechanical attachment structure arranged with the leadless body portion and configured to engage an adrenal gland or periadrenal connective tissue of a patient; and

at least one electrode arranged with the leadless body portion and configured to deliver stimulation energy to modulate catecholamine release from chromaffin cells within the adrenal gland.

2. The implantable medical device of claim 1, wherein the mechanical attachment structure comprises at least one of a barb, a rigid helix and at least one talon.

3. The implantable medical device of claim 1, wherein the leadless body portion comprises a first side and a second side, and the mechanical attachment structure comprises a plurality of talons arranged on the second side of the leadless body portion.

4. The implantable medical device of claim 3, wherein the plurality of talons are configured to deploy to engage the adrenal gland or periadrenal connective tissue in response deployment from a deployment system in a deployed configuration and collapse to a delivery configuration in response to retraction within the deployment system.

5. The implantable medical device of claim 3, wherein at least one of the plurality of talons is the electrode arranged with the leadless body portion and configured to deliver the stimulation energy to modulate catecholamine release from chromaffin cells within the adrenal gland.

6. The implantable medical device of claim 1, wherein the leadless body portion comprises a first side and a second side, the at least one electrode is arranged on the first side, and the mechanical attachment structure comprises a plurality of protrusions arranged on the second side of the leadless body portion and configured to attach to the adrenal gland for mechanical attachment thereto.

7. The implantable medical device of claim 6, wherein the plurality of protrusions include at least one of:

angled relative to the second side of the leadless body portion, and perpendicular to the second side of the leadless body portion.

8. The implantable medical device of claim 1, wherein the leadless body portion comprises a first side and a second side, the at least one electrode is arranged on the first side, and the second side of the leadless body portion includes the mechanical attachment structure, and the mechanical attachment structure comprises a roughened surface configured to engage the adrenal gland for mechanical attachment thereto.

9. The implantable medical device of claim 1, wherein the leadless body portion comprises a first end section, a second end section, and an intermediate section between the first end section and the second end section, and the first end section and the second end section having a greater flexibility than the intermediate section.

10. The implantable medical device of claim 9, wherein the first end section and the second end section of the leadless body portion are configured to enhance engagement of the adrenal gland for mechanical attachment thereto.

11. An adrenal gland stimulation system comprising:

an implantable leadless device configured to deliver electrostimulation therapy to a patient, the implantable leadless device comprising;

a body portion,

a mechanical attachment structure arranged with the leadless body portion and configured to engage an adrenal gland or periadrenal connective tissue of the patient,

at least one electrode arranged with the body portion and configured to deliver stimulation energy to modulate catecholamine release from chromaffin cells within the adrenal gland, and

a physiological sensor configured to measure at least one physiological parameter, and alter the stimulation energy in response thereto.

12. The system of claim 11, wherein the implantable leadless device further comprises a communications component configured to communicate wireless signals.

13. The system of claim 12, further comprising a co-implanted device configured to transmit the wireless signals to the communications component, the wireless signals include data instructing the at least one electrode to deliver the stimulation energy on a duty cycle based on a metabolization time of catecholamine.

14. The system of claim 13, wherein the co-implanted device is further configured to transmit data via the wireless signals instructing the at least one electrode to deliver the stimulation energy at a frequency between 2 Hz and 20 kHz.

15. The system of claim 11, wherein the physiological sensor configured to measure at least one of:

heart rate of the patient, heart rate variability of the patient, respiration rate of the patient, activity level of the patient, catecholamine levels of the patient, metanephrine levels of the patient, body temperature of the patient, cardiac output of the patient, and arterial pressure of the patient.

16. A method of delivering therapy to an adrenal gland of a patient, the method comprising:

delivering a leadless implantable medical device to the adrenal gland, the leadless implantable medical device including a mechanical attachment structure;

attaching a leadless implantable medical device to an adrenal gland or periadrenal connective tissue via the mechanical attachment structure; and

delivering stimulation energy through at least one of a plurality of electrodes leadless implantable medical device to modulate catecholamine release from chromaffin cells within the adrenal gland.

17. The method of claim 16, wherein attaching the portion of the leadless implantable medical device comprises attaching the portion of the leadless implantable medical device to a capsule of the adrenal gland.

18. The method of claim 17, wherein attaching the portion of the leadless implantable medical device to the capsule comprises attaching the leady body to at least one of:

an exterior surface of the capsule of the adrenal gland, an interior surface of the capsule of the adrenal gland, and between the interior surface and the exterior surface of the capsule of the adrenal gland.

19. The method of claim 16, wherein mechanical attachment structure comprises at least one of a barb, a rigid helix and at least one talon.

20. The method of claim 16, wherein mechanical attachment structure comprises a plurality of protrusions arranged with the leadless implantable medical device.