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METHODS FOR PERFORMING SPATIAL PROFILING OF BIOLOGICAL MATERIALS

  • US 20180057873A1
  • Filed: 04/18/2016
  • Published: 03/01/2018
  • Est. Priority Date: 04/17/2015
  • Status: Active Application
First Claim
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1. A method comprising:

  • a) contacting a biological sample comprising a plurality of biological molecules with a spatial barcode array, wherein the spatial barcode array comprises a plurality of oligonucleotides attached thereto, wherein each of the plurality of oligonucleotides comprises a barcode sequence that identifies a location of the plurality of oligonucleotides on the spatial barcode array;

    b) attaching the plurality of oligonucleotides to the plurality of biological molecules to generate a plurality of tagged biological molecules;

    c) sequencing at least a portion of the plurality of tagged biological molecules; and

    d) determining a location of the plurality of biological molecules within the biological sample based on the barcode sequence attached to the tagged biological molecules.

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