FLUORESCENT METHODS AND MATERIALS FOR DIRECTED BIOMARKER SIGNAL AMPLIFICATION
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Abstract
Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.
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Citations
84 Claims
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1-71. -71. (canceled)
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72. A multichromophore-biomolecule conjugate comprising:
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a sensor biomolecule covalently linked to a light harvesting multichromophore via a bioconjugation site; wherein the light harvesting multichromophore is a conjugated polymer of π
-conjugated repeat units comprising a fluorene unit of the structure; - View Dependent Claims (73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84)
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Specification