MULTISPOT MONITORING FOR USE IN OPTICAL COHERENCE TOMOGRAPHY

• US 20180064381A1
• Filed: 10/31/2017
• Published: 03/08/2018
• Est. Priority Date: 03/04/2008
• Status: Active Grant

• Current Assignee: Masimo Corporation
• Original Assignee: Masimo Corporation
• Inventors: Shakespeare, Walter J., Bennett, William Henry, Iceman, Jason T., Apple, Howard P., Wallace, Phillip William, Schurman, Matthew J.
• Granted Patent: US 11,033,210 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 2576/00 Medical imaging apparatus involving image processing or analysis A61B1/00009, A61B6/52 and A61B8/52 take precedence; image processing per se G06T; details of algorithms for analysing medical images G06T7/0012
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/4875 Hydration status, fluid retention of the body
• CPC Class Codes: A61B 5/7221 Determining signal validity, reliability or quality A61B5/7207 and A61B5/7217 take precedence
• CPC Class Codes: A61B 5/725 using specific filters therefor, e.g. Kalman or adaptive filters A61B5/316 take precedence
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence

Abstract

Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.

Claims

1. (canceled)

2. An apparatus for conducting multiple-scale scanning with an optical coherence tomography system, comprising:

a beam scanner configured to be utilized with an optical coherence tomography apparatus to detect an analyte level in a scanned tissue, the beam scanner configured to adjust movement of a beam on at least two-different length scales, comprising;

(i) a coarse-scale wherein the beam moves over a distance large enough such that the beam scanner probes a plurality of sites, and

(ii) a measurement-scale wherein the beam moves over a distance smaller than the site-scale, optical coherence tomography measurements taken over the measurement-scale being capable of providing analyte measurement correlation.

3. The apparatus of claim 2, wherein the beam scanner is configured to move the beam over the site-scale such that each of the plurality of sites corresponds with a unique spatial area.

4. The apparatus of claim 2, wherein the beam scanner is configured to move the beam over the measurement-scale such that a measure of the analyte level in the scanned site can be determined.

5. The apparatus of claim 2, wherein the beam scanner is configured to scan the entire area of at least one of the plurality of sites.

6. The apparatus of claim 2, wherein the beam scanner comprises:

a first optical element configured to move the beam on at least one of the site-scale and the measurement-scale.

7. The apparatus of claim 6, wherein the first optical element comprises a moveable mirror.

8. The apparatus of claim 6, wherein the beam scanner further comprises:

a second optical element configured to move the beam on the site-scale, wherein the first optical element is configured to move the beam on the measurement-scale.

9. The apparatus of claim 8, wherein the second optical element comprises a rotatable prism.

10. A method for conducting multiple-scale scanning with an optical coherence tomography system, the method comprising:

directing a beam scanner, configured to be utilized with an optical coherence tomography apparatus to detect an analyte level in a scanned tissue, to adjust movement of a beam on at least two-different length scales, comprising;

(i) a coarse-scale wherein the beam moves over a distance large enough such that the beam scanner probes a plurality of sites, and

(ii) a measurement-scale wherein the beam moves over a distance smaller than the site-scale, optical coherence tomography measurements taken over the measurement-scale being capable of providing analyte measurement correlation; and

based on the optical coherence tomography measurements taken over the measurement-scale, detect the analyte level in the scanned tissue.

11. The method of claim 10, wherein the beam scanner is configured to move the beam over the site-scale such that each of the plurality of sites corresponds with a unique spatial area.

12. The method of claim 10, wherein the beam scanner is configured to move the beam over the measurement-scale such that a measure of the analyte level in the scanned site can be determined.

13. The method of claim 10, wherein the beam scanner is configured to scan the entire area of at least one of the plurality of sites.

14. The method of claim 10, wherein the beam scanner comprises:

a first optical element configured to move the beam on at least one of the site-scale and the measurement-scale.

15. The method of claim 14, wherein the first optical element comprises a moveable mirror.

16. The method of claim 14, wherein the beam scanner further comprises:

a second optical element configured to move the beam on the site-scale, wherein the first optical element is configured to move the beam on the measurement-scale.

17. The method of claim 16, wherein the second optical element comprises a rotatable prism.