COMPOUNDING DEVICE, SYSTEM, KIT, SOFTWARE, AND METHOD

• US 20180065097A1
• Filed: 10/30/2017
• Published: 03/08/2018
• Est. Priority Date: 04/23/2015
• Status: Active Grant

• Current Assignee: B Braun Medical Incorporated (B. Braun Holding GmbH & Co. KG)
• Original Assignee: B Braun Medical Incorporated (B. Braun Holding GmbH & Co. KG)
• Inventors: Konrad, JR., Karl, Bartholomew, Joel, Janders, Mike, Ammermann, Linda M., Lane, Benjamin R., Mumpower, Mariano, Pearl, Aaron S.
• Granted Patent: US 10,617,863 B2
• Time in Patent Office: Days
• CPC Class Codes: A61J 2200/70 Device provided with specific sensor or indicating means
• CPC Class Codes: A61J 3/00 Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C
• CPC Class Codes: A61M 2039/229 Stopcocks
• CPC Class Codes: A61M 39/22 Valves or arrangement of valves A61M39/02, A61M39/0247, A61M39/16 take precedence; regulating valves in infusion systems A61M5/16881; in devices worn by the patient for the reception of urine, faeces, catamenial or other discharge, or in colostomy devices A61F5/4405
• CPC Class Codes: A61M 39/223 Multiway valves
• CPC Class Codes: A61M 39/24 Check- or non-return valves
• CPC Class Codes: B01F 2101/06 Mixing of food ingredients
• CPC Class Codes: B01F 2101/22 Mixing of ingredients for pharmaceutical or medical compositions
• CPC Class Codes: B01F 2101/2202 Mixing compositions or mixers in the medical or veterinary field
• CPC Class Codes: B01F 2101/2204 Mixing chemical components in generals in order to improve chemical treatment or reactions, independently from the specific application
• CPC Class Codes: B01F 23/45 using flow mixing
• CPC Class Codes: B01F 23/451 by injecting one liquid into another
• CPC Class Codes: B01F 25/1051 of the mixing valve type
• CPC Class Codes: B01F 25/30 Injector mixers mixing by creating vortex flow B01F25/10
• CPC Class Codes: B01F 25/31 in conduits or tubes through which the main component flows
• CPC Class Codes: B01F 33/30 Micromixers
• CPC Class Codes: B01F 33/3017 Mixing chamber
• CPC Class Codes: B01F 33/84 Mixing plants with mixing receptacles receiving material dispensed from several component receptacles, e.g. paint tins
• CPC Class Codes: B01F 33/846 using stored recipes for determining the composition of the mixture to be produced, i.e. for determining the amounts of the basic components to be dispensed from the component receptacles
• CPC Class Codes: B01F 35/7176 : using pumps
• CPC Class Codes: B01F 35/717611 : Peristaltic pumps
• CPC Class Codes: B01F 35/71805 : using valves, gates, orifices or openings
• CPC Class Codes: B65B 3/12 : mechanically, e.g. by pistons or pumps
• CPC Class Codes: F16K 11/085 : with cylindrical plug
• CPC Class Codes: F16K 11/0856 : having all the connecting conduits situated in more than one plane perpendicular to the axis of the plug
• CPC Class Codes: F16K 11/22 : with an actuating member for each valve, e.g. interconnected to form multiple-way valves
• CPC Class Codes: F16K 2099/0084 : Chemistry or biology, e.g. "lab-on-a-chip" technology
• CPC Class Codes: F16K 31/041 : for rotating valves F16K31/055 takes precedence
• CPC Class Codes: F16K 5/04 : with plugs having cylindrical surfaces; Packings therefor
• CPC Class Codes: F16K 5/0407 : with particular plug arrangements, e.g. particular shape or built-in means
• CPC Class Codes: F16K 5/0414 : Plug channel at 90 degrees to the inlet
• CPC Class Codes: F16K 99/0013 : Rotary valves
• CPC Class Codes: F16K 99/0042 : Electric operating means therefor

Abstract

An exemplary manifold for a pharmaceutical ingredient compounding device can include a housing, at least one primary intake port including a primary valve to permit or block passage of at least one primary ingredient through the manifold, and a plurality of secondary intake ports. A first channel can be in fluid communication with the at least one primary valve and include an outlet port configured to outlet the at least one primary ingredient from the manifold. A second channel can be in fluid communication with a plurality of secondary valves and include an outlet port configured to outlet at least one of a plurality of secondary ingredients from the manifold. The first channel and second channel can be in fluid isolation from each other such that the at least one primary ingredient does not mix with the plurality of secondary ingredients within the manifold.

Claims

1. A manifold for a compounding device configured for compounding pharmaceutical ingredients, comprising:

a housing having a top surface and a bottom surface;

at least one primary intake port extending away from the top surface of the housing and including a primary valve configured to open and close the at least one primary intake port to permit or block passage of at least one primary ingredient through the manifold, the at least one primary intake port having a primary intake port axis along which ingredients flow when entering the manifold during use;

a plurality of secondary intake ports located on the first side of the housing, each of the secondary intake ports including a secondary valve configured to open and close a respective one of the plurality of secondary intake ports to permit or block passage of a plurality of secondary ingredients through the manifold, the plurality of second intake ports each having a secondary intake port axis along which one of the secondary ingredients flows when entering the manifold during use, and at least one secondary intake port axis is parallel with the primary intake port axis;

a first channel in fluid communication with the at least one primary valve and including an outlet port configured to outlet the at least one primary ingredient from the manifold, wherein the at least one primary valve is located adjacent to the first channel of the manifold;

a second channel in fluid communication with the plurality of secondary valves and including an outlet port configured to outlet at least one of the plurality of secondary ingredients from the manifold, wherein the secondary valves are located adjacent to the second channel of the manifold; and

a primary valve housing extending from the bottom surface of the housing and configured to house the primary valve,

wherein the first channel and second channel are in fluid isolation from each other such that the at least one primary ingredient does not mix with the plurality of secondary ingredients within the manifold.

2. The manifold of claim 1, wherein the primary valve housing extends from a side of the housing opposite a side on which the at least one primary intake port is located.

3. The manifold of claim 1, wherein the primary valve is configured to receive a valve key extending from the compounding device such that rotation of the valve key actuates the primary valve.

4. The manifold of claim 1, wherein the outlet port of the first channel has a first outlet axis along which ingredients flow, and the outlet port of the second channel has a second outlet axis along which ingredients flow, and the first outlet axis and the second outlet axis are transverse with respect to the primary intake port axis.

5. The manifold of claim 1, wherein a cross-sectional area of a fluid pathway defined by the first channel and taken normal to a longitudinal axis of the first channel is smaller than a cross-sectional area of a fluid pathway defined by the second channel and taken normal to a longitudinal axis of the second channel.

6. The manifold of claim 1, wherein the at least one primary intake port is configured to be connected to at least one primary connection line, and the plurality of secondary intake ports are configured to be connected to a respective one of a plurality of secondary connection lines, wherein a cross-sectional area taken normal to a longitudinal axis of the at least one primary connection line is smaller than a cross-sectional area taken normal to a longitudinal axis for each of the plurality of secondary connection lines.

7. The manifold of claim 1, wherein the at least one primary intake port has a cross-sectional area normal to the primary intake port axis along which fluid travels that is smaller than a cross-sectional area normal to the secondary intake port axis along which fluid travels in each of the plurality of secondary intake ports.

8. The manifold of claim 1, wherein the first channel includes a socket located at an end opposite an output port of the first channel.

9. The manifold of claim 1, wherein the at least one primary intake port includes a plurality of primary intake ports, a first plurality of the primary intake ports having a primary diameter and a second plurality of the primary intake ports having a secondary diameter, and the primary diameter being smaller than the secondary diameter.

10. The manifold of claim 9, wherein each of the plurality of secondary intake ports has a diameter substantially equal to the secondary diameter.

11. The manifold of claim 1, further comprising a sensor configured to confirm that the housing is in a correct and operational position with respect to the compounding device.

12. The manifold of claim 1, wherein at least one of the at least one primary valve and the secondary valves includes a wall configured to require fluid to turn greater than 90 degrees along a fluid pathway after entering a valve inlet and prior to exiting a side outlet of the at least one of the at least one primary valve and the secondary valves.

13. The manifold of claim 1, wherein the housing of the manifold includes an attachment structure configured to removeably attach the housing of the manifold to a housing of the compounding device.

14. The manifold of claim 13, wherein the primary valve includes a mating structure configured to mate with a primary actuator member located on the compounding device when the manifold is attached to the housing of the compounding device, and each of the secondary valves includes a mating structure configured to mate with a secondary valve actuator member located on the compounding device when the manifold is attached to the housing of the compounding device.

15. The manifold of claim 1, further comprising:

at least one primary valve actuator connection structure extending from the bottom surface of the housing and configured to mate with and be actuated by at least one actuator located on the compounding device; and

a plurality of secondary valve actuator connection structures extending from the bottom surface of the housing and configured to mate with at least one secondary actuator located on the compounding device.

16. A manifold for a compounding device configured for compounding pharmaceutical liquids, comprising:

a housing;

at least one primary intake port located on the housing and including a primary valve configured to open and close the at least one primary intake port to permit or block passage of at least one primary liquid ingredient through the manifold, the at least one primary intake port having a primary port intake axis along which liquid flows;

a plurality of secondary intake ports located on the housing, each of the secondary intake ports including a secondary valve configured to open and close a respective one of the plurality of secondary intake ports to permit or block passage of a plurality of liquid secondary ingredients through the manifold, each of the secondary intake ports having a secondary intake port axis along which liquid flows;

a first channel in fluid communication with the at least one primary valve and including an outlet port configured to outlet the at least one primary liquid ingredient from the manifold, the outlet port of the first channel having a first channel outlet port axis along which liquid flows; and

a second channel in fluid communication with the plurality of secondary valves and including an outlet port configured to outlet at least one of the plurality of secondary liquid ingredients from the manifold, the outlet port of the second channel having a second channel outlet port axis along which liquid flows,

wherein the first channel and second channel are in fluid isolation from each other such that the at least one primary liquid ingredient does not mix with the plurality of secondary liquid ingredients within the manifold,

wherein the at least one primary valve is located adjacent and in fluid communication with the first channel of the manifold such that liquid selectively enters the first channel of the manifold depending on a state of actuation of the at least one primary valve,

wherein the secondary valves are located adjacent and in fluid communication with the second channel of the manifold such that liquid selectively enters the second channel of the manifold depending on a state of actuation of the secondary valves, and

wherein the first channel outlet port axis and the second channel outlet port axis are transverse with respect to the primary intake port axis and at least one of the secondary intake port axes.

17. The manifold of claim 16, wherein a cross-sectional area of a fluid pathway defined by the first channel and taken normal to a longitudinal axis of the first channel is smaller than a cross-sectional area of a fluid pathway defined by the second channel and taken normal to a longitudinal axis of the second channel.

18. The manifold of claim 16, wherein the at least one primary intake port is configured to be connected to at least one primary connection line, and the plurality of secondary intake ports are configured to be connected to a respective one of a plurality of secondary connection lines, wherein a cross-sectional area taken normal to a longitudinal axis of the at least one primary connection line is smaller than a cross-sectional area taken normal to a longitudinal axis for each of the plurality of secondary connection lines.

19. The manifold of claim 16, wherein the at least one primary intake port has a cross-sectional area normal to an axis in which fluid travels that is smaller than a cross-sectional area normal to an axis in which fluid travels in each of the plurality of secondary intake ports.

20. The manifold of claim 16, wherein an inner diameter of the first channel is equal to an inner diameter of the second channel.

21. The manifold of claim 16, wherein the at least one primary intake port includes a plurality of primary intake ports, a first plurality of the primary intake ports having a primary diameter and a second plurality of the primary intake ports having a secondary diameter, and the primary diameter being smaller than the secondary diameter.

22. The manifold of claim 21, wherein each of the plurality of secondary intake ports has a diameter substantially equal to the secondary diameter.

23. The manifold of claim 16, further comprising a sensor configured to confirm that the housing is in a correct and operational position with respect to the compounding device.

24. The manifold of claim 16, wherein at least one of the at least one primary valve and the secondary valves includes a wall configured to require fluid to turn greater than 90 degrees along a fluid pathway after entering a valve inlet and prior to exiting a side outlet of the at least one of the at least one primary valve and the secondary valves.

25. The manifold of claim 16, wherein the housing of the manifold includes an attachment structure configured to removeably attach the housing of the manifold to a housing of the compounding device.

26. The manifold of claim 25, wherein the primary valve includes a mating structure configured to mate with a primary actuator member located on the compounding device when the manifold is attached to the housing of the compounding device, and each of the secondary valves includes a mating structure configured to mate with a secondary valve actuator member located on the compounding device when the manifold is attached to the housing of the compounding device.

27. The manifold of claim 16, further comprising:

at least one primary valve actuator connection structure located adjacent the housing and configured to mate with and be actuated by at least one actuator located on the compounding device; and

a plurality of secondary valve actuator connection structures located adjacent the housing and configured to mate with at least one secondary actuator located on the compounding device.