METHODS AND DEVICES FOR STIMULATING CELL PROLIFERATION

• US 20180078339A1
• Filed: 08/09/2017
• Published: 03/22/2018
• Est. Priority Date: 02/26/2016
• Status: Abandoned Application

• Current Assignee: Advanced Orthodontics and Education Association, LLC
• Original Assignee: Advanced Orthodontics and Education Association, LLC
• Inventors: Johnson, Richard, Way, Bryce A.
• Application Number:
  US15/672,981
• Publication Number:
  US 20180078339A1
• Time in Patent Office: Days
• CPC Class Codes: A61C 17/20 using ultrasonics
• CPC Class Codes: A61C 19/06 Implements for therapeutic treatment radiation therapy A61N5/00
• CPC Class Codes: A61C 2202/00 Packaging for dental appliances
• CPC Class Codes: A61C 7/00 Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
• CPC Class Codes: A61C 7/008 using vibrating means
• CPC Class Codes: A61C 7/08 Mouthpiece-type retainers or positioners, e.g. for both the lower and upper arch arch-shaped medicament applicators for teeth or gums A61C19/063; mouthguards for protecting the teeth of sportsmen A63B71/085
• CPC Class Codes: A61C 7/36 Devices acting between upper and lower teeth
• CPC Class Codes: A61C 8/0006 Periodontal tissue or bone regeneration support means for endoprosthetic bone substitute or bone graft implants A61F2/2846
• CPC Class Codes: A61K 35/32 Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
• CPC Class Codes: A61K 35/33 Fibroblasts

Abstract

Embodiments of the present disclosure are directed to devices and methods for stimulating cell proliferation. In one implementation, a method for increasing cell proliferation is provided. The method includes providing a vibrational dental device configured to vibrate at a frequency higher than about 80 Hz. The method also includes mechanically stimulating, using the vibrational dental device, cells for less than about 20 minutes daily over a period of time. The number of the cells at the end of the period of time is increased. The cells may include one of human osteoblasts and fibroblasts.

Claims

1. A method for increasing periodontal cell proliferation, the method comprising:

providing a vibrational dental device configured to vibrate at a frequency higher than about 80 Hz;

mechanically stimulating, using the vibrational dental device, periodontal cells, including at least one of human osteoblasts and fibroblasts, for about 5 minutes daily over a period of time; and

wherein the number of the periodontal cells at the end of the period of time is increased.

2. The method of claim 1, wherein the vibrational dental device is configured to vibrate at an acceleration magnitude ranging between about 0.03 G and about 0.2 G.

3. The method of claim 1, further comprising mechanically stimulating the cells at a frequency between about 100 Hz and about 120 Hz.

4. The method of claim 1, further comprising mechanically stimulating the cells at a g-force between about 0.03 G and about 0.2 G.

5. The method of claim 1, wherein the vibrational dental device comprises a mouthpiece and a motor connected to and configured to vibrate the mouthpiece.

6. The method of claim 5, further comprising providing the mouthpiece between the occlusal surfaces of a user'"'"'s teeth to be clamped by the user'"'"'s teeth.

7. The method of claim 6, further comprising applying an axial vibratory force on the occlusal surfaces by the vibrational dental device.

8. The method of claim 1, further comprising detecting vibration characteristics of the mouthpiece.

9. The method of claim 1, further comprising adjusting the frequency and/or g-force of the vibration of the vibrational dental device.

10. The method of claim 1, wherein the period of time ranges from a couple of days to a few months.

11. The method of claim 10, wherein the period of time ranges from a couple of days to a few days.

12. The method of claim 10, wherein the period of time ranges from a few days to couple of weeks.

13. The method of claim 10, wherein the period of time ranges from a month to a couple of months.

14. The method of claim 10, wherein the period of time ranges from a couple of months to a few months.

15. The method of claim 1, wherein the human osteoblasts comprise human osteoblasts in alveolar bone.

16. The method of claim 1, wherein the fibroblasts comprise periodontal ligament fibroblasts.

17. A method for accelerating orthodontic tooth movement, the method comprising:

providing a mouthpiece of a vibrational dental device to be clamped by the user'"'"'s teeth; and

mechanically stimulating, using the vibrational dental device, cells of the user, including at least one of osteoblasts in alveolar bone and periodontal ligament fibroblasts, for about 5 minutes daily at a frequency higher than about 80 Hz over a period of time.

18. The method of claim 17, further comprising providing the mouthpiece between the occlusal surfaces of a user'"'"'s teeth.

19. The method of claim 17, further comprising mechanically stimulating the cells of the user at a g-force between about 0.03 G and about 0.2 G.

20. The method of claim 17, further comprising mechanically stimulating the cells of the user at a frequency between about 100 Hz and about 120 Hz.

21. A dental device for increasing cell proliferation, the dental device comprising means for

mechanically stimulating cells, including at least one of human osteoblasts and periodontal ligament fibroblasts, at a frequency higher than about 80 Hz for about 5 minutes daily over a period of time;

and

increasing the number of the cells at the end of the period of time.