COMPOSITIONS AND METHODS FOR PREVENTING COLORECTAL CANCER

• US 20180078587A1
• Filed: 03/17/2016
• Published: 03/22/2018
• Est. Priority Date: 03/18/2015
• Status: Active Application

• Current Assignee: Trustees of Tufts College
• Original Assignee: Trustees of Tufts College
• Inventors: Crott, Jimmy W.
• Application Number:
  US15/558,835
• Publication Number:
  US 20180078587A1
• Time in Patent Office: Days
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/7076 containing purines, e.g. adenosine, adenylic acid
• CPC Class Codes: A61K 35/74 Bacteria therapeutic use of a bacterial protein A61K38/00
• CPC Class Codes: A61K 35/741 Probiotics probiotic yeast, e.g. saccharomyces A61K36/06
• CPC Class Codes: A61K 9/50 Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals A61K9/2081 takes precedence; particles with a single coating comprising drug A61K9/167

Abstract

Provided herein are compositions and methods for preventing and/or reducing the risk of colorectal cancer. In particular, provided herein are probiotic and small molecule agents and their use in preventing colorectal cancer.

Claims

1. A method of preventing colorectal cancer, comprising:

providing a composition comprising adenosine and/or a composition comprising a bacterium of the species Parabacteroides to a subject.

2. The method of claim 1, wherein said bacterium is Parabacteroides distasonis.

3. The method of claim 1, wherein said subject is at risk for colorectal cancer.

4. The method of claim 3, wherein said risk is the result of a clinical finding selected from the group consisting of a family history of colorectal cancer, a prior history of colorectal cancer, a finding of a polyp or precancerous lesion during colonoscopy, and a finding of a molecular marker associated with colorectal cancer.

5. The method of claim 1, wherein said subject has been diagnosed with inflammatory bowel disease.

6. The method of claim 1, wherein said subject has not been diagnosed with inflammatory bowel disease.

7. The method of claim 1, wherein said subject is overweight or obese.

8. The method of claim 1, wherein said subject is not overweight or obese.

9. The method of claim 1, wherein said bacterium and said adenosine are separately microencapsulated.

10. The method of claim 1, wherein said bacterium and said adenosine are provided in a single composition.

11. A composition comprising adenosine and a bacterium of the genus Parabacteroides.

12. The composition of claim 11, wherein said bacterium is Parabacteroides distasonis.