DEVICES AND METHODS FOR SAMPLE ANALYSIS
First Claim
1. A digital microfluidic and analyte detection device, comprising:
- a first substrate and a second substrate aligned generally parallel to each other to define a gap therebetween, the first substrate comprising a plurality of electrodes to generate electrical actuation forces on a liquid droplet disposed in the gap;
at least one reagent disposed on at least one of the first substrate or the second substrate and configured to be carried by the liquid droplet; and
an analyte detection device in fluid communication with the gap, wherein the plurality of electrodes are configured to move the liquid droplet towards the analyte detection device.
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Abstract
Integrated microfluidic and analyte detection devices are disclosed, along with methods of detecting target analytes. Digital microfluidic and analyte detection devices include a first substrate and a second substrate aligned generally parallel to each other to define a gap therebetween, the first substrate including a plurality of electrodes to generate electrical actuation forces on a liquid droplet disposed in the gap; at least one reagent disposed on at least one of the first substrate or the second substrate and configured to be carried by the liquid droplet; and an analyte detection device in fluid communication with the gap, wherein the plurality of electrodes are configured to move the liquid droplet towards the analyte detection device.
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Citations
20 Claims
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1. A digital microfluidic and analyte detection device, comprising:
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a first substrate and a second substrate aligned generally parallel to each other to define a gap therebetween, the first substrate comprising a plurality of electrodes to generate electrical actuation forces on a liquid droplet disposed in the gap; at least one reagent disposed on at least one of the first substrate or the second substrate and configured to be carried by the liquid droplet; and an analyte detection device in fluid communication with the gap, wherein the plurality of electrodes are configured to move the liquid droplet towards the analyte detection device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of detecting an analyte of interest, comprising:
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introducing a liquid droplet comprising an analyte of interest into a device comprising; a first substrate and a second substrate aligned generally parallel to each other to define a gap therebetween, the first substrate comprising a plurality of electrodes to generate electrical actuation forces on a liquid droplet disposed in the gap; at least one reagent disposed on at least one of the first substrate or the second substrate and configured to be carried by the liquid droplet; and an analyte detection device in fluid communication with the gap, wherein the plurality of electrodes are configured to move the liquid droplet towards the analyte detection device; actuating at least one electrode to move the liquid droplet towards the analyte detection device; labeling the analyte of interest with a detectable label; and detecting the detectable label. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification