METHODS AND DEVICES FOR NEUROMODULATION OF THE ADRENAL GLAND

• US 20180104480A1
• Filed: 12/19/2017
• Published: 04/19/2018
• Est. Priority Date: 08/23/2016
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Swanson, Lynne E., Stoffregen, William C., Clark, Bryan A., Govea, Michael X., Werner, Dennis B., Brill, Natalie A., Thakur, Pramodsingh H.
• Granted Patent: US 10,583,286 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61B 5/4227 endocrine glands, i.e. thyroid, adrenals, hypothalamic, pituitary
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61F 2007/0075 using a Peltier element, e.g. near the spot to be heated or cooled
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61N 1/0553 Paddle shaped electrodes, e.g. for laminotomy
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: A61N 1/0558 Anchoring or fixation means therefor
• CPC Class Codes: A61N 1/36031 using physiological parameters for adjustment
• CPC Class Codes: A61N 1/3606 adapted for a particular treatment
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/36171 Frequency
• CPC Class Codes: A61N 1/36175 Pulse width or duty cycle

Abstract

Aspects of the present disclosure are directed toward apparatuses, systems, and methods for delivering therapy to an adrenal gland of a patient. The apparatuses, systems, and methods may include a housing and a plurality of electrodes arranged with the housing. In addition, one or more of the plurality of electrodes may deliver stimulation energy to modulate L-dopa release.

Claims

1. An apparatus for delivering therapy to an adrenal gland of a patient, the apparatus comprising:

a housing configured to attach to a portion of the adrenal gland of the patient; and

a plurality of stimulation elements arranged with the housing, the plurality of electrodes being configured to deliver stimulation energy through at least one of the plurality of electrodes to modulate release of L-dopa into a bloodstream of the patient.

2. The apparatus of claim 1, wherein the plurality of stimulation elements are configured to stimulate the adrenal gland and release of L-dopa into the blood stream to maintain dopamine levels of the patient within a zone.

3. The apparatus of claim 1, wherein the housing is a leadless body housing configured to engage the portion of the adrenal gland.

4. The apparatus of claim 1, wherein the housing is a lead body configured to engage the portion of the adrenal gland.

5. The apparatus of claim 1, wherein the plurality of stimulation elements are configured to deliver at least one of electrical stimulation, light stimulation, sound stimulation, thermal stimulation, and magnetic stimulation to the adrenal gland to modulate the release of L-dopa.

6. The apparatus of claim 1, further comprising a sensor configured to measure the L-dopa levels within the patient and alter the stimulation energy delivered through the at least one of the plurality of stimulation elements to maintain the L-dopa release within a zone.

7. The apparatus of claim 6, wherein the sensor is at least one of a vascular sensor configured to measure hypotension, a sensor configured to measure blood pressure of the patient, a bioimpedence sensor configured to measure blood pressure of the patient, an electoral sensor configured to assess vascular tone or heart pulse transit time, an optical sensor configured to assess vascular tone or heart pulse transit time, and an accelerometer configured to measure physical movement of the patient.

8. The apparatus of claim 7, wherein the housing comprises a communications component configured to communicate wireless signals, and the sensor is configured to measure the dopamine levels associated with L-dopa within the patient and communicate feedback to the communications component via wireless signals to alter the stimulation energy delivered through the at least one of the plurality of stimulation elements to maintain the L-dopa release within a zone.

9. The apparatus of claim 1, wherein the plurality of stimulation elements are configured to delivery stimulation energy on a duty cycle based on a metabolization time of L-dopa within the patient.

10. The apparatus of claim 1, wherein the delivery of stimulation energy modulates release of L-dopa to lessen at least one of tremors, muscle rigidity, and bradykinesia of the patient.

11. The apparatus of claim 1, wherein the plurality of stimulation elements are configured to intermittently or continuously instruct delivery of the stimulation energy through the plurality of electrodes.

12. A system for delivering therapy to an adrenal gland of a patient, the system comprising:

a housing configured to attach to a portion of the adrenal gland of the patient;

a plurality of stimulation elements arranged with the housing, the plurality of electrodes being configured to deliver stimulation energy through at least one of the plurality of electrodes to modulate release of L-dopa into a bloodstream of the patient; and

a sensor configured to measure dopamine levels within the patient associated with the L-dopa release and alter the stimulation energy delivered through the at least one of the plurality of stimulation elements in response thereto.

13. The system of claim 12, wherein the sensor is at least one of a vascular sensor configured to measure hypotension, a sensor configured to measure blood pressure of the patient, a bioimpedence sensor configured to measure blood pressure of the patient, an electoral sensor configured to assess vascular tone or heart pulse transit time, an optical sensor configured to assess vascular tone or heart pulse transit time, and an accelerometer configured to measure physical movement of the patient.

14. The system of claim 12, wherein the sensor is configured to measure a physical symptom of the patient associated with Parkinson'"'"'s disease.

15. The system of claim 12, wherein the controller is further configured to instruct delivery of the stimulation energy through the at least one of the plurality of electrodes at a frequency between 2 Hz and 20 kHz.

16. The system of claim 12, wherein the plurality of stimulation elements are configured to stimulate the adrenal gland and release of L-dopa into the blood stream to maintain dopamine levels of the patient within a zone

17. A method of delivering therapy to an adrenal gland of a patient, the method comprising:

delivering a housing to a portion of the adrenal gland of the patient, the housing including a plurality of stimulation elements arranged with the housing; and

delivering stimulation energy through at least one of a plurality of electrodes leadless implantable medical to modulate aldosterone levels within the patient.

18. The method of claim 17, further comprising delivering stimulation energy to peripheral sympathetic nerves to modulate the release of L-dopa into the bloodstream.

19. The method of claim 17, further comprising delivering deep brain stimulation energy to the patient delivering stimulation energy.

20. The method of claim 17, further comprising measuring a physical symptom of the patient associated with Parkinson'"'"'s disease and altering delivery of the stimulation in response thereto.