PARTICLE SIZE DETERMINATION USING RAMAN SPECTROSCOPY
First Claim
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1. A method for determining the size of particles dispersed in a light-transmissive medium, comprising:
- directing an excitation light into the medium, wherein the excitation light is monochromatic;
collecting from the medium a first Raman spectrum using a Raman spectrometer;
analyzing the first Raman spectrum to determine a composition of the medium;
computing a first ratio of red light in the first Raman spectrum to blue light in the first Raman spectrum;
waiting a pre-determined period of time;
after the pre-determined period, directing the excitation light into the medium and collecting from the medium a second Raman spectrum using the Raman spectrometer;
computing a second ratio of red light in the second Raman spectrum to blue light in the second Raman spectrum;
comparing the second ratio to the first ratio; and
determining the size and a count of particles dispersed in the medium based on the comparison of the second ratio to the first ratio.
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Abstract
The present disclosure is directed to a method of particle size determination for particles suspended within a light-transmissive medium. The method includes directing a monochromatic light source into the medium and collecting from the medium a Raman-scattered light spectrum. The method includes analyzing the Raman spectrum to determine an amount of Tyndall scattering of the Raman spectrum caused by particles within the medium, and thus determine the size and the number of particles mediating the Tyndall scattering.
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20 Claims
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1. A method for determining the size of particles dispersed in a light-transmissive medium, comprising:
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directing an excitation light into the medium, wherein the excitation light is monochromatic; collecting from the medium a first Raman spectrum using a Raman spectrometer; analyzing the first Raman spectrum to determine a composition of the medium; computing a first ratio of red light in the first Raman spectrum to blue light in the first Raman spectrum; waiting a pre-determined period of time; after the pre-determined period, directing the excitation light into the medium and collecting from the medium a second Raman spectrum using the Raman spectrometer; computing a second ratio of red light in the second Raman spectrum to blue light in the second Raman spectrum; comparing the second ratio to the first ratio; and determining the size and a count of particles dispersed in the medium based on the comparison of the second ratio to the first ratio. - View Dependent Claims (2, 3, 4, 5)
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6. A method for controlling a crystal nucleation process within a light-transmissive medium, comprising:
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directing an excitation light into the medium, wherein the excitation light is monochromatic; collecting from the medium a first Raman spectrum using a Raman spectrometer; analyzing the first Raman spectrum to determine a composition of the medium; computing a first ratio of red light in the first Raman spectrum to blue light in the first Raman spectrum; optionally changing a parameter of the nucleation process; waiting a pre-determined period of time; after the pre-determined period, directing the excitation light into the medium; collecting from the medium a second Raman spectrum using the Raman spectrometer; computing a second ratio of red light in the second Raman spectrum to blue light in the second Raman spectrum; comparing the second ratio to the first ratio; determining the size and a count of particles dispersed in the medium based on the comparison of the second ratio to the first ratio; and repeating the changing, the waiting, the directing, the collecting, the computing, the comparing, and the determination of particle size and count until a pre-determined crystal nucleation state is reached. - View Dependent Claims (7, 8, 9, 10, 11)
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12. A system for determining particle size in a light-transmissive medium, comprising:
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at least one probe embodied to direct laser light into a sample including particles dispersed in a light-transmissive medium and to collect Raman emission spectra from the sample, wherein the Raman emission spectra illuminate the dispersed particles; a detector configured to receive the collected Raman emission spectra from the sample; and a processor configured to analyze the collected Raman emission spectra to determine the size of particles resulting from the illumination of the particles by the Raman emission spectra. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification