CONTINUOUSLY EMISSIVE CORE/SHELL NANOPLATELETS

• US 20180106813A1
• Filed: 03/25/2016
• Published: 04/19/2018
• Est. Priority Date: 03/27/2015
• Status: Active Application

• Current Assignee: Nexdot
• Original Assignee: Nexdot
• Inventors: HEUCLIN, Hadrien, NADAL, Brice, GRAZON, Chloe
• Application Number:
  US15/561,746
• Publication Number:
  US 20180106813A1
• Time in Patent Office: Days
• CPC Class Codes: A61K 49/0019 characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
• CPC Class Codes: A61K 49/0067 quantum dots, fluorescent nanocrystals
• CPC Class Codes: B82Y 20/00 Nanooptics, e.g. quantum optics or photonic crystals
• CPC Class Codes: B82Y 40/00 Manufacture or treatment of nanostructures
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: C09K 11/025 non-luminescent particle coatings or suspension media
• CPC Class Codes: C09K 11/565 with zinc cadmium
• CPC Class Codes: C09K 11/883 with zinc or cadmium
• CPC Class Codes: G01N 33/582 with fluorescent label
• CPC Class Codes: G01N 33/587 Nanoparticles
• CPC Class Codes: G01N 33/588 with semiconductor nanocrystal label, e.g. quantum dots
• CPC Class Codes: Y10S 977/755 Nanosheet or quantum barrier/well, i.e. layer structure having one dimension or thickness of 100 nm or less
• CPC Class Codes: Y10S 977/824 Group II-VI nonoxide compounds, e.g. CdxMnyTe
• CPC Class Codes: Y10S 977/896 Chemical synthesis, e.g. chemical bonding or breaking
• CPC Class Codes: Y10S 977/927 Diagnostic contrast agent

Abstract

The present invention relates to a core/shell nanoplatelet and its use as a fluorophore or a fluorescent agent.

Claims

1-15. -15. (canceled)

16. A population of fluorescent colloidal nanoplatelets, each member of the population comprising an initial nanoplatelet comprising a core including a first semiconductor material or a core/shell including a first semiconductor material/second material and a shell including a second semiconductor material on the surface of the initial nanoplatelet,

wherein the thickness of the shell is at least 3 nm and

wherein the population exhibits fluorescence quantum efficiency decrease of less than 50% after one hour under light illumination.

17. The population of fluorescent colloidal nanoplatelets according to claim 16, wherein the population exhibits fluorescence quantum efficiency at 100°

C. or above that is at least 80% of the fluorescence quantum efficiency of the population at 20°

C.

18. The population of fluorescent colloidal nanoplatelets according to claim 16, wherein at least 40% of the nanoplatelets of the population are continuously emissive for a period of at least one minute.

19. The population of fluorescent colloidal nanoplatelets according to claim 16, wherein the shell of the nanoplatelet has a thickness of at least 5 nm.

20. The population of fluorescent colloidal nanoplatelets according to claim 16, wherein the shell of the nanoplatelet has a thickness of at least 6 nm.

21. The population of fluorescent colloidal nanoplatelets according to claim 16, wherein the shell of the nanoplatelet has a thickness of at least 8 nm.

22. The population of fluorescent colloidal nanoplatelets according to claim 16, wherein the shell of the nanoplatelet has a thickness of at least 10 nm.

23. The population of fluorescent colloidal nanoplatelets according to claim 16, wherein the material composing the core and the shell comprises a material M_xE_y wherein:

M is selected from group Ib, IIa, IIb, IIIa, IIIb, IVa, IVb, Va, Vb, VIb, VIIb, VIII or mixtures thereof;

E is selected from group Va, VIa, VIIa or mixtures thereof; and

x and y are independently a decimal number from 0 to 5.

24. The population of fluorescent colloidal nanoplatelets according to claim 16, wherein the material composing the core and the shell comprises a material M_xE_y, wherein:

M is Zn, Cd, Hg, Cu, Ag, Au, Ni, Pd, Pt, Co, Fe, Ru, Os, Mn, Tc, Re, Cr, Mo, W, V, Nd, Ta, Ti, Zr, Hf, Be, Mg, Ca, Sr, Ba, Al, Ga, In, Tl, Si, Ge, Sn, Pb, As, Sb, Bi, Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, or a mixture thereof;

E is O, S, Se, Te, N, P, As, F, Cl, Br, I, or a mixture thereof; and

x and y are independently a decimal number from 0 to 5.

25. A process of growth of a population of fluorescent colloidal nanoplatelets according to claim 16, comprising the steps of injecting the initial colloidal nanoplatelets in a solvent at a temperature ranging from 200°

C. to 460°

C. and subsequently a precursor of E or M, wherein said precursor of E or M is injected slowly in order to control the shell growth rate; and

wherein the precursor of respectively M or E is injected either in the solvent before injection of the initial colloidal nanoplatelets or in the mixture simultaneously with the precursor of respectively E or M, wherein;

M is selected from group Ib, IIa, IIb, IIIa, IIIb, IVa, IVb, Va, Vb, VIb, VIIb, VIII or mixtures thereof;

E is selected from group Va, VIa, VIIa or mixtures thereof; and

x and y are independently a decimal number from 0 to 5.

26. The process according to claim 25, wherein a fraction of the precursor'"'"'s mixture is mixed with the initial colloidal nanoplatelets before injection in the solvent.

27. A fluorophore comprising a fluorescent colloidal nanoplatelet according to claim 16.

28. A detection system comprising the fluorescent colloidal nanoplatelet according to claim 16.

29. The detection system according to claim 28, wherein the detection system is an affinity assay, fluorescent staining, flow cytometry, nucleic acid sequencing, nucleic acid hybridization, nucleic acid synthesis or amplification, or molecular sorting.

30. An in vivo animal imaging method or an ex vivo live cells imaging method comprising providing the fluorescent colloidal nanoplatelet accord according to claim 16, and applying such fluorescent colloidal nanoplatelet to perform said imaging.