OLIGOSACCHARIDE MIXTURE AND FOOD PRODUCT COMPRISING SAME

• US 20180110253A1
• Filed: 12/12/2017
• Published: 04/26/2018
• Est. Priority Date: 11/23/2010
• Status: Active Grant

• Current Assignee: Societe des Produits Nestle SA (Nestle SA)
• Original Assignee: Nestec SA (Nestle SA)
• Inventors: Sprenger, Norbert, Neeser, Jean-Richard
• Granted Patent: US 10,716,321 B2
• Time in Patent Office: Days
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23L 33/21 Addition of substantially indigestible substances, e.g. dietary fibres
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/3202 Prebiotics, ingredients fermented in the gastrointestinal tract by beneficial microflora
• CPC Class Codes: A23V 2250/28 Oligosaccharides
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/702 Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/02 Immunomodulators

Abstract

Oligosaccharide mixtures consisting of at least one N-acetyl-lactosamine, at least one sialylated oligosaccharide, and at least one fucosylated oligosaccharide are provided. Food products, especially infant formula, comprising the oligosaccharide mixture are also provided.

Claims

1. An oligosaccharide mixture consisting of:

at least one acetyl-N-lactosamine;

at least one sialylated oligosaccharide; and

at least one fucosylated oligosaccharide.

2. The oligosaccharide mixture of claim 1, wherein the acetyl-N-lactosamine is selected from the group consisting of lacto-N-tetraose and lacto-N-neotetraose, the sialylated oligosaccharide is selected from the group consisting of 3′

-sialyllactose and 6′

-sialyllactose, and the fucosylated oligosaccharide is selected from the group consisting of 2′

-fucosyllactose, 3-fucosyllactose, difucosyllactose, lacto-N-fucopentaoses, lacto-N-difucohexaose I, monofucosyllacto-N-hexaose, Difucosyliacto-N-hexaose I and Difucosyllacto-N-neohexaose II.

3. The oligosaccharide mixture of claim 1, wherein the acetyl-N-lactosamine consists of lacto-N-neotetraose, the sialylated oligosaccharide consists of 6′

-sialyllactose, and the fucosylated oligosaccharide consists of 2′

-fucosyllactose.

4. The oligosaccharide mixture of claim 1, which is synthetic or derived from animal milk.

5. A food product comprising:

oligosaccharide mixture consisting of at least one acetyl-N-lactosamine, at least one sialylated oligosaccharide, and at least one fucosylated oligosaccharide.

6. The food product of claim 5, wherein the acetyl-N-lactosamine is selected from the group consisting of lacto-N-tetraose and lacto-N-neotetraose, the sialylated oligosaccharide is selected from the group consisting of 3′

-sialyllactose and 6′

-sialyllactose, and the fucosylated oligosaccharide is selected from the group consisting of 2′

-fucosyllactose, 3-fucosyllactose, difucosyllactose, lacto-N-fucopentaoses, lacto-N-difucohexaose I, monofucosyllacto-N-hexaose, Difucosyllacto-N-hexaose I and Difucosyllacto-N-neohexaose II.

7. The food product of claim 5, wherein the acetyl-N-lactosamine consists of lacto-N-neotetraose, the sialylated oligosaccharide consists of 6′

-sialyllactose, and the fucosylated oligosaccharide, consists of 2′

-fucosyllactose.

8. The food product of claim 5 comprising about 0.2 to about 5 grams of the oligosaccharide mixture per liter of the food product.

9. The food product of claim 5 comprising a protein source, a fat source and a carbohydrate source.

10. The food product of claim 5, which is selected from the group consisting of a starter infant formula, an infant formula, a baby food, an infant cereal composition, a follow-up formula and a growing-up milk.

11. The food product of claim 5 comprising at least one probiotic bacterial strain.

12. The food product of claim 5 comprising Bifidobacterium longum and hydrolyzed proteins.

13. The food product of claim 5 comprising a fat source that has a ratio of n-6 to n-3 fatty acids of about 8:

1 to 10;

1.

14. The food product of claim 5, for use in the enhancement of the oral tolerance to allergens.