CONTROLLED EXPOSURE OF IN-VIVO SENSORS
First Claim
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1. A method, comprising:
- forming a sensing surface on a surface of the an in-vivo sensor, the sensing surface comprising a first sensor and a second sensor having different thicknesses and compositions, the first sensor binding to a first analyte of interest a second sensor binding to a second analyte of interest;
coating the first sensor with a first bioabsorbable polymeric coating comprising a first bioabsorbable polymer, the first bioabsorbable polymeric coating covering and surrounding the first sensor and having a thickness in a range from about 50 to about 1,000 nanometers (nm);
coating the second sensor with a second bioabsorbable polymeric comprising a second bioabsorbable polymer, the second bioabsorbable polymeric coating covering and surrounding the second sensor and having a thickness in a range from about 50 to about 1,000 nm; and
sterilizing the in-vivo sensor, at elevated temperature and high pressure, after coating the sensing surface with the bioabsorbable polymeric coating; and
implanting the in-vivo sensor in an individual, the second bioabsorbable coating desorbing over time to expose the second sensor, and the first bioabsorbable coating desorbing subsequent to the first bioabsorbable coating to expose the first sensor.
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Abstract
A method of protecting an in-vivo sensor includes forming a sensing surface on a surface of the in-vivo sensor, the sensing surface including a functionalized monolayer that will bind to an analyte of interest; and coating the sensing surface of the sensor with a bioabsorbable polymeric coating including a bioabsorbable polymer; wherein the bioabsorbable polymeric coating is configured to protect the in-vivo sensor until needed for implantation.
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Citations
21 Claims
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1. A method, comprising:
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forming a sensing surface on a surface of the an in-vivo sensor, the sensing surface comprising a first sensor and a second sensor having different thicknesses and compositions, the first sensor binding to a first analyte of interest a second sensor binding to a second analyte of interest; coating the first sensor with a first bioabsorbable polymeric coating comprising a first bioabsorbable polymer, the first bioabsorbable polymeric coating covering and surrounding the first sensor and having a thickness in a range from about 50 to about 1,000 nanometers (nm); coating the second sensor with a second bioabsorbable polymeric comprising a second bioabsorbable polymer, the second bioabsorbable polymeric coating covering and surrounding the second sensor and having a thickness in a range from about 50 to about 1,000 nm; and sterilizing the in-vivo sensor, at elevated temperature and high pressure, after coating the sensing surface with the bioabsorbable polymeric coating; and implanting the in-vivo sensor in an individual, the second bioabsorbable coating desorbing over time to expose the second sensor, and the first bioabsorbable coating desorbing subsequent to the first bioabsorbable coating to expose the first sensor. - View Dependent Claims (3, 4, 8, 11, 12, 13, 14, 17, 18, 20, 21)
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2. (canceled)
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5. (canceled)
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6. (canceled)
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9. (canceled)
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15. (canceled)
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19. (canceled)
Specification