METHOD OF ANALYSING GAS CHROMATOGRAPHY DATA

• US 20180128794A1
• Filed: 01/11/2018
• Published: 05/10/2018
• Est. Priority Date: 04/02/2012
• Status: Active Grant

• Current Assignee: I-Vigilant Technologies Limited
• Original Assignee: I-Vigilant Technologies Limited
• Inventors: SUTAN, Anwar
• Granted Patent: US 10,670,570 B2
• Time in Patent Office: Days
• CPC Class Codes: G01N 2030/201 multiport valves, i.e. having more than two ports
• CPC Class Codes: G01N 2030/202 rotary valves
• CPC Class Codes: G01N 2030/207 with metering cavity, e.g. sample loop
• CPC Class Codes: G01N 30/8665 for calibrating the measuring apparatus
• CPC Class Codes: G01N 30/8675 Evaluation, i.e. decoding of the signal into analytical information for analysis of specific compounds see also G01N30/88 and subgroups of G01N33/00; chemical libraries per se C40B

Abstract

A method of analysing gas chromatography data is described. The method, a first response factor data set acquired from a gas chromatograph (GC) apparatus during a procedure on a calibration or reference gas sample at a first time is received. One or more additional response factor data sets acquired from the gas chromatograph apparatus during a procedure on a calibration or reference gas sample from one or more later times are received. The method comprises calculating a measure of uncertainty for at least one compound of the reference gas sample from the first and additional response factor data sets. The one or more later times are during an operational period of the gas chromatograph apparatus. The measure of uncertainty may be used to, for example, identify the necessity to perform a maintenance action in the GC or to assess whether the GC is in a healthy or unhealthy condition.

Claims

1. A method of determining an operating condition of a gas chromatograph comprising:

receiving a first response factor data set acquired from a gas chromatograph (GC) apparatus during a procedure on a calibration or reference gas sample at a first time;

receiving one or more additional response factor data sets acquired from the gas chromatograph apparatus during a procedure on a calibration or reference gas sample from one or more later times, wherein the one or more later times are during an operational period of the gas chromatograph apparatus;

calculating a measure of uncertainty for at least one compound of the reference gas sample from the first and additional response factor data sets;

wherein calculating a measure of uncertainty comprises calculating a relative sensitivity of a desired gas property to a change in concentration of at least one compound; and

comparing the calculated measure of uncertainty to a predetermined threshold value to determine an operating condition of the GC apparatus.

2. The method according to claim 1, wherein the calibration or reference gas sample is a working reference mixture.

3. The method according to claim 1, wherein the operational period is a period in which the gas chromatograph apparatus is in normal use.

4. The method according to claim 1, wherein the one or more additional response factor data sets comprises a plurality of data sets acquired over the operational period.

5. The method according to claim 4, wherein the one or more additional response factor data sets comprises data sets acquired at regular or irregular intervals interspersed between performing tests on unknown gas samples, and wherein the method comprises calculating an updated measure of uncertainty data at regular or irregular intervals during the period of operation.

6. The method according to claim 1, comprising calculating the measure of uncertainty data after every calibration of the GC.

7. The method according to claim 1, comprising calculating the measure of uncertainty data using historical reference data generated when the GC is known or assumed to be functioning correctly.

8. The method according to claim 1, wherein calculating a measure of uncertainty comprises calculating normalised compositions derived from calculated peak areas and/or historical response factors.

9. The method according to claim 1, wherein calculating a measure of uncertainty comprises calculating a standard relative uncertainty.

10. The method according to claim 1, wherein calculating a measure of uncertainty comprises calculating a combined relative uncertainty value.

11. The method according to claim 1, comprising calculating the combined relative uncertainty value by combining two or more of:

a relative uncertainty of the calibration gas, an uncertainty of at least one compound derived from the GC reproducibility and/or a repeatability relative uncertainty.

12. The method according to claim 1, comprising calculating a combined relative uncertainty value for multiple compounds.

13. The method according to claim 1, wherein calculating a measure of uncertainty comprises calculating a combined standard uncertainty of a gas property by combining a calculated relative sensitivity of a desired gas property with a standard relative uncertainty.

14. The method according to claim 1 wherein calculating a measure of uncertainty comprises calculating a combined relative uncertainty value, and wherein calculating a combined standard uncertainty of a gas property comprises combining a calculated relative sensitivity of the desired gas property with a combined relative uncertainty.

15. The method according to claim 1, wherein calculating a measure of uncertainty comprises calculating a combined expanded uncertainty of a gas property.

16. The method according to claim 1, comprising identifying or scheduling a requirement for one or more maintenance operations on the GC apparatus.

17. The method according to claim 16, wherein the one or more maintenance operations is selected form the group consisting of:

a general troubleshooting to identify components of the GC which are not in a correct functional state;

a general maintenance service in which at least one common maintenance action is performed;

changing a GC valve;

replacing the calibration gas;

or changing one or more columns.

19. A computerised method of analysing gas chromatography data comprising performing the method of the any of claim 1 in a computer system.

18. A method of determining an operating condition of a gas chromatography comprising:

receiving a first response factor data set acquired from a gas chromatograph apparatus during a procedure on a calibration or reference gas sample at a first time;

receiving one or more additional response factor data sets acquired from the gas chromatograph apparatus during a procedure on a calibration or reference gas sample from one or more later times;

wherein the one or more later times are when the gas chromatograph apparatus is in situ or on site in a gas sample analysis facility;

calculating a measure of uncertainty for at least one compound of the reference gas sample from the first and additional response factor data sets; and

comparing the calculated measure of uncertainty to a predetermined threshold value to determine an operating condition of the GC apparatus.