ANTISENSE NUCLEIC ACIDS
First Claim
1. An antisense oligomer which causes skipping of the 55th exon in the human dystrophin gene, consisting of a nucleotide sequence complementary to any one of the nucleotide sequences consisting of the 10th to the 31st, the 10th to the 32nd, the 11th to the 31st, the 11th to the 32nd, the 13th to the 34th, the 13th to the 35th, the 13th to the 36th, 14th to the 35th, the 14th to the 36th, the 15th to the 35th, the 15th to the 36th, the 16th to the 34th, the 16th to the 35th, and the 16th to the 36th nucleotides, from the 5′
- end of the 55th exon in the human dystrophin gene.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides a pharmaceutical agent which causes skipping of the 55th, 45th, 50th or 44th exon in the human dystrophin gene with a high efficiency.
The present invention provides an oligomer which efficiently enables to cause skipping of the 55th, 45th, 50th or 44th exon in the human dystrophin gene.
6 Citations
22 Claims
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1. An antisense oligomer which causes skipping of the 55th exon in the human dystrophin gene, consisting of a nucleotide sequence complementary to any one of the nucleotide sequences consisting of the 10th to the 31st, the 10th to the 32nd, the 11th to the 31st, the 11th to the 32nd, the 13th to the 34th, the 13th to the 35th, the 13th to the 36th, 14th to the 35th, the 14th to the 36th, the 15th to the 35th, the 15th to the 36th, the 16th to the 34th, the 16th to the 35th, and the 16th to the 36th nucleotides, from the 5′
- end of the 55th exon in the human dystrophin gene.
- View Dependent Claims (6, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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2-5. -5. (canceled)
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7-12. -12. (canceled)
Specification