ANTI-MICROBIAL ARTICLES AND METHODS OF USING SAME

• US 20180154037A1
• Filed: 06/29/2016
• Published: 06/07/2018
• Est. Priority Date: 06/29/2015
• Status: Active Grant

• Current Assignee: Solventum Intellectual Properties Company (Solventum Corp.)
• Original Assignee: 3M Innovative Properties Company (3M Company)
• Inventors: Yu, Ta-Hua, Liu, Junkang Jacob, Stepanova, Narina Y., Veeraraghavan, Badri, David, Moses M.
• Granted Patent: US 11,571,490 B2
• Time in Patent Office: Days
• CPC Class Codes: A61F 13/00063 comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00
• CPC Class Codes: A61F 13/01029 made of multiple layers
• CPC Class Codes: A61F 13/05 specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
• CPC Class Codes: A61L 15/18 containing inorganic materials
• CPC Class Codes: A61L 15/24 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof A61L15/225 takes precedence
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 2420/02 Methods for coating medical devices

Abstract

An article having anti-microbial effect is provided. The article includes an occlusive layer and a substrate having a nanostructured surface. The nanostructured surface is coated with a metal oxide layer and the metal oxide layer includes a metal oxide.

Claims

1. An article comprising:

an occlusive layer; and

a substrate having a nanostructured surface;

wherein the nanostructured surface is coated with a metal oxide layer;

wherein the metal oxide layer comprises a metal oxide.

2. The article of claim 1, wherein the metal oxide layer comprises less than 99 wt. % non-oxidized metal.

3. The article of claim 2, wherein the metal oxide layer comprises less than 95 wt. % non-oxidized metal.

4. The article of claim 3, wherein the nanostructured surface comprises an anisotropic nanostructure.

5. The article of claim 4, wherein the anisotropic nanostructure has an aspect ratio greater than 2:

1.

6. The article of claim 1, wherein the metal oxide is selected from silver oxide, copper oxide, gold oxide, zinc oxide, magnesium oxide, titanium oxide, chromium oxide and combinations thereof.

7. The article of claim 6, wherein the metal oxide is silver oxide.

8. The article of claim 7, wherein the silver oxide is Ag₂O.

9. The article of claim 8, wherein Ag⁺ release concentration of the article is more than 3.5 ppm.

10. The article of claim 9, wherein Ag⁺ release concentration of the article is more than 5 ppm.

11. The article of any of claim 10, wherein Ag⁺ release concentration of the article is more than 8 ppm.

12. The article of claim 1, wherein the metal oxide layer is formed by physical vapor deposition.

13. The article of claim 1, wherein the article exhibits a more than 4 log reduction of bacterial growth within 7 days.

14. The article of claim 1, wherein the article exhibits a more than 6 log reduction of bacterial growth within 7 days.

15. A method of use the article of claim 1, comprising of

providing the article of claim 1;

and

applying the article to a subject;

wherein the article exhibits a more than 4 log reduction of bacterial growth within 7 days.