METHODS OF TREATING AUTOIMMUNE AND ALLOIMMUNE DISORDERS
First Claim
1. A method of reducing the level of autoantibody or alloantibody titers in an individual afflicted with an autoimmune or alloimmune disorder, the method comprisingadministering to the individual an antibody that specifically binds complement component is (Cis) in an amount and for a period effective to reduce the level of autoantibody or alloantibody titers.
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Abstract
The present disclosure provides methods of treating an alloimmune or autoimmune disorder in an individual; the methods involve administering to the individual an effective amount of an antibody specific for complement component C1s. The present disclosure provides a method of monitoring the efficacy of a subject treatment method; the method involves detecting the level of autoantibody or alloantibody in a biological sample obtained from the individual.
7 Citations
35 Claims
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1. A method of reducing the level of autoantibody or alloantibody titers in an individual afflicted with an autoimmune or alloimmune disorder, the method comprising
administering to the individual an antibody that specifically binds complement component is (Cis) in an amount and for a period effective to reduce the level of autoantibody or alloantibody titers.
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10. A method of reducing B-cell proliferation in an individual afflicted with an autoimmune or alloimmune disorder, the method comprising
administering to the individual an antibody that specifically binds complement component is (C1s) in an amount and for a period effective to reduce B-cell proliferation.
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19. A method of reducing B-cell activation in an individual afflicted with an autoimmune or alloimmune disorder, the method comprising
administering to the individual an antibody that specifically binds complement component is (Cis) in an amount and for a period effective to reduce B-cell activation.
- 31. A method of monitoring the efficacy of a treatment method comprising administering an anti-C1s antibody, the monitoring method comprising detecting a level of autoantibody or alloantibody in a biological sample obtained from the individual, wherein a decrease in the level of autoantibody or alloantibody, compared to a pre-treatment level, indicates efficacy of the treatment.
Specification