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CONJUGATED COMPOUNDS COMPRISING CYSTEINE-ENGINEERED ANTIBODIES

  • US 20180169255A1
  • Filed: 04/10/2015
  • Published: 06/21/2018
  • Est. Priority Date: 04/11/2014
  • Status: Active Grant
First Claim
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1. A conjugate compound comprising a cysteine-engineered antibody or Fc fusion protein and at least one heterologous moiety, wherein:

  • (i) the Fc domain of the antibody or Fc fusion protein comprises a cysteine amino acid insertion between positions 239 and 240, wherein the amino acid position numbering is according to the EU index as set forth in Kabat; and

    (ii) wherein at least one heterologous moiety is conjugated to the cysteine amino acid insertion between positions 239 and 240.

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