Mitochondria-Targeted Lapachone Compounds and Uses Therefor
First Claim
Patent Images
1. A compound comprising a mitochondria-targeting group covalently linked to β
- -lapachone or a β
-lapachone derivative, or a pharmaceutically-acceptable salt or ester thereof.
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Accused Products
Abstract
Compounds, compositions and methods useful for treating cancer and neiirodegeneration are provided. The compounds comprise a mitochondria-targeting moiety linked to β-lapachone or a β-lapachone derivative.
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Citations
20 Claims
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1. A compound comprising a mitochondria-targeting group covalently linked to β
- -lapachone or a β
-lapachone derivative, or a pharmaceutically-acceptable salt or ester thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- -lapachone or a β
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12. A composition comprising a first compound comprising a mitochondria-targeting group covalently linked to β
- -lapachone or a β
-lapachone derivative, or a pharmaceutically-acceptable salt or ester thereof, and a pharmaceutically-acceptable excipient. - View Dependent Claims (13, 14)
- -lapachone or a β
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15. A method of treating a cancer in a patient, comprising administering to a patient an amount of a first compound comprising a mitochondria-targeting group covalently linked to β
- -lapachone or a β
-lapachone derivative, or a pharmaceutically-acceptable salt or ester thereof effective to increase reactive oxygen species (ROS) in mitochondria of cancer cells of a patient. - View Dependent Claims (16, 17, 18)
- -lapachone or a β
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19. A method of treating neurodegeneration, comprising administering to a patient an amount of a compound comprising a mitochondria-targeting group covalently linked to β
- -lapachone or a β
-lapachone derivative, or a pharmaceutically-acceptable salt or ester thereof effective to decrease reactive oxygen species (ROS) production in mitochondria of a cell of a patient.
- -lapachone or a β
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20. A method of decreasing oxidative damage in a patient comprising administering to a patient an amount of a compound comprising a mitochondria-targeting group covalently linked to β
- -lapachone or a β
-lapachone derivative, or a pharmaceutically-acceptable salt or ester thereof effective to decrease reactive oxygen species (ROS) production in mitochondria of a cell of a patient.
- -lapachone or a β
Specification