KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
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Abstract
Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
21 Citations
93 Claims
- 1. A compound having a structure of formula (I)
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2. A compound having a structure of formula (I)
- 3. A compound having a structure of formula (II)
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4. A compound having a structure of formula (II)
- 10. A compound having a structure of formula (III) or (III′
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11. A compound having a structure of formula (III) or (III′
- );
- );
- 22. A compound having a structure of formula (IV) or (IV′
-
23. A compound having a structure of formula (IV) or (IV′
- );
- );
- 28. A compound having a structure of formula (V):
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29. A compound having a structure of formula (V):
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85. A compound as recited in Table 1.
- 91. A compound having a structure selected from:
Specification