SERPIN FUSION POLYPEPTIDES AND METHODS OF USE THEREOF
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Abstract
This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and second polypeptide comprising of at least one the following: an Fc polypeptide or an amino acid sequence that is derived from an Fc polypeptide; a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide; a WAP domain containing polypeptide or a sequence derived from a WAP containing polypeptide; and an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules.
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Citations
73 Claims
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1-53. -53. (canceled)
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54. An isolated fusion protein for inhibiting serine proteases having at least one human alpha-1 antitrypsin (AAT) polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO;
2, SEQ ID NO;
32, and SEQ ID NO;
33, wherein the AAT polypeptide is operably linked to an immunoglobulin Fc polypeptide having an amino acid sequence that is at least 98% identical to the amino acid sequence of SEQ ID NO;
6. - View Dependent Claims (55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 68, 69, 70, 71, 72, 73)
- 1, SEQ ID NO;
Specification