NUTRITIONAL SUPPLEMENT COMPOSITION SUITABLE FOR IMPROVING LEAN TISSUE MASS STATUS IN AN ADULT HUMAN

• US 20180184700A1
• Filed: 05/26/2015
• Published: 07/05/2018
• Est. Priority Date: 05/30/2014
• Status: Active Grant

• Current Assignee: University of Limerick
• Original Assignee: University of Limerick
• Granted Patent: US 10,455,853 B2
• Time in Patent Office: Days
• CPC Class Codes: A23L 33/00 Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
• CPC Class Codes: A23L 33/155 Vitamins A or D
• CPC Class Codes: A23L 33/16 Inorganic salts, minerals or trace elements
• CPC Class Codes: A23L 33/18 Peptides; Protein hydrolysates
• CPC Class Codes: A23L 33/19 Dairy proteins
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 31/593 9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 38/018 from milk
• CPC Class Codes: A61K 38/1709 from mammals
• CPC Class Codes: A61K 9/009 Sachets, pouches characterised by the material or function of the envelope with gastric retention A61K9/0065; sachets which are not administered but function merely as a container are classified according to the content, e.g. sachets comprising powder for reconstitution of a drink A61K9/0095
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system

Abstract

“A nutritional supplement composition suitable for improving lean tissue mass status in a mammal” A nutritional supplement suitable for increasing lean tissue mass in a mammal comprises protein, vitamin D, and calcium. The protein comprises a casein-based milk protein composition, a hydrolysed whey-based milk protein composition having insulinotropic bioactivity, and a hydrolysed whey-based milk protein composition having anti-oxidant bioactivity. The supplement increases lean tissue mass in a subject.

Claims

1. A nutritional supplement suitable for increasing lean tissue mass in a mammal, the supplement comprising per 100 g dry weight at least 60 g of a protein component, 0.01 to 0.1 mg vitamin D, and 1 to 5 g calcium, and in which the protein component comprises:

50-60 g of a casein-based milk protein composition,

5-15 g of a first hydrolysed whey-based milk protein composition having insulinotropic bioactivity; and

4-8 g of a second hydrolysed whey-based milk protein composition having antioxidant bioactivity.

2. A nutritional supplement as claimed in claim 1, in which the protein component comprises:

52-56 g of a casein-based milk protein composition,

11.7-12.5 g of the first hydrolysed whey-based milk protein composition; and

5.8-6.2 g of the second whey-based milk protein composition.

3. A nutritional supplement as claimed in claim 1, and comprising:

60-80 g of the protein component;

3-4 g calcium; and

0.04-0.07 mg vitamin D.

4. A nutritional supplement as claimed in claim 1, and comprising:

67-73 g of the protein component;

2.5-3 g calcium; and

0.05-0.06 mg vitamin D.

5. A nutritional supplement as claimed in claim 1, in which the casein-based milk protein composition is a milk protein concentrate.

6. A nutritional supplement as claimed in claim 1, in which the first hydrolysed whey-based milk protein composition having insulinotropic activity is enzymatically hydrolysed whey protein concentrate having a degree of hydrolysis of 30-35% DH.

7. A nutritional supplement as claimed in claim 1, in which the second hydrolysed whey-based milk protein composition having anti-oxidant activity is enzymatically hydrolysed whey protein isolate having a degree of hydrolysis of 42-47% DH.

8. A nutritional supplement composition as claimed in claim 1 in which the essential amino acid content of the protein is at least 40 g/100 g protein.

9. A nutritional supplement according to claim 1 and provided in the form of a single dose suitable for administration with a meal, and comprising 8 to 17 g protein, 6 to 13 μ

g vitamin D, and 250 to 500 mg calcium per dose.

10. A nutritional supplement as claimed in claim 1 provided in the form of a single dose suitable for administration with a meal, and comprising 8 to 17 g protein, 6 to 13 μ

g vitamin D, and 250 to 500 mg calcium per dose and as a powder in a sachet.

11. A nutritional supplement as claimed in claim 1 provided in the form of a single dose suitable for administration with a meal, and comprising 8 to 17 g protein, 6 to 13 μ

g vitamin D, and 250 to 500 mg calcium per dose and as a powder divided between two sachets, in which the sachets are provided as a single package unit with a tear line dividing the two sachets.

12. A non-therapeutic method of improving lean tissue mass status, physical capacity or bone quality in a mammal, comprising the step of administering a nutritional supplement as claimed in claim 1 to the mammal.

13. A non-therapeutic method according to claim 12 comprising the step of administering said nutritional supplement in two doses daily, in which each of the two doses is administered with a separate minor meal, and in which each dose comprises 8 to 17 g protein, 6 to 13 μ

g vitamin D, and 250 to 500 mg calcium.

16. A method of preventing or treating a disease or condition associated with lean tissue mass degradation in a mammal comprising administering the nutritional supplement of claim 1.

17. A method according to claim 16 in which the disease is sarcopaenia.

18. A method of preventing or treating a disease or condition associated with lean tissue mass degradation in a mammal of claim 16, in which the nutritional supplement is administered in two doses, each dose with a separate minor meal, and in which each dose comprises 8 to 17 g protein, 6 to 13 μ

g vitamin D, and 250 to 500 mg calcium.

22. A non-therapeutic method of claim 12 in which the metric of bone quality is selected from bone protein content and bone protein quality.

14. (canceled)

15. (canceled)

19. (canceled)

20. (canceled)

21. (canceled)