SYSTEM AND SIGNATURES FOR A MULTI-MODAL PHYSIOLOGICAL PERIODIC BIOMARKER ASSESSMENT

• US 20180184964A1
• Filed: 06/30/2015
• Published: 07/05/2018
• Est. Priority Date: 06/30/2014
• Status: Abandoned Application

• Current Assignee: Cerora, Inc.
• Original Assignee: Cerora, Inc.
• Application Number:
  US15/323,238
• Publication Number:
  US 20180184964A1
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/0017 transmitting optical signals transmission by light H04B10/00
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/0533 Measuring galvanic skin response
• CPC Class Codes: A61B 5/1176 Recognition of faces
• CPC Class Codes: A61B 5/125 objective methods
• CPC Class Codes: A61B 5/162 Testing reaction times
• CPC Class Codes: A61B 5/163 by tracking eye movement, gaze, or pupil change
• CPC Class Codes: A61B 5/167 Personality evaluation
• CPC Class Codes: A61B 5/168 Evaluating attention deficit, hyperactivity
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/339 Displays specially adapted therefor
• CPC Class Codes: A61B 5/375 using biofeedback
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/4803 Speech analysis specially adapted for diagnostic purposes
• CPC Class Codes: A61B 5/4884 inducing physiological or psychological stress, e.g. applications for stress testing
• CPC Class Codes: A61B 5/6803 Head-worn items, e.g. helmets, masks, headphones or goggles
• CPC Class Codes: A61B 5/7405 using sound
• CPC Class Codes: A61B 5/7475 User input or interface means, e.g. keyboard, pointing device, joystick
• CPC Class Codes: G06F 1/14 : Time supervision arrangements, e.g. real time clock
• CPC Class Codes: G09C 1/00 : Apparatus or methods whereby a given sequence of signs, e.g. an intelligible text, is transformed into an unintelligible sequence of signs by transposing the signs or groups of signs or by replacing them by others according to a predetermined system cryptographic typewriters G09C3/00
• CPC Class Codes: G16H 50/20 : for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: H04L 67/12 : specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
• CPC Class Codes: H04W 4/70 : Services for machine-to-machine communication [M2M] or machine type communication [MTC]

Abstract

Methods for diagnosing Autism and/or Autism Spectrum Disorder (ASD) of a subject include establishing baseline brain wave patterns of the subject by having the subject perform a series of task and measuring brain waves during the tasks using an EEG measurement device, applying a light stimulus or images to the subject'"'"'s eyes and capturing eye movements and/or changes in facial expression in response to the light stimulus or images, and giving a neuropsychological and cognition battery of tasks to the subject to generate a provoked cognitive assessment of the subject. A processing device correlates the baseline brain wave patterns, eye movements and/or facial expressions, and provoked cognitive assessment of the subject to profile data indicative of Autism and/or ASD. The corresponding system may also include an auditory testing device that tests the subject'"'"'s sensitivity to sound and records the subject'"'"'s speech in response to verbal tasks. The processing device performs language processing of the recorded speech and correlates the processed language to the profile data indicative of Autism and/or ASD.

Claims

1. A method of diagnosing Autism and/or Autism Spectrum Disorder (ASD) of a subject, comprising:

a) establishing baseline brain wave patterns of the subject by having the subject perform a series of task and measuring brain waves during said tasks using an EEG measurement device;

b) applying a light stimulus or images to the subject'"'"'s eyes and capturing eye movements and/or changes in facial expression in response to the light stimulus or images;

c) giving a neuropsychological and cognition battery of tasks to the subject to generate a provoked cognitive assessment of the subject; and

d) correlating the baseline brain wave patterns, eye movements and/or facial expressions, and provoked cognitive assessment of the subject to profile data indicative of Autism and/or ASD.

2. A method as in claim 1, further comprising repeating steps a) through d) periodically.

3. A method as in claim 1, wherein said step of establishing baseline brain wave patterns includes performing saccade and/or anti-saccade tests on the subject.

4. A method as in claim 1, wherein said step of applying light stimulus or images to the subject'"'"'s eyes include showing the subject static images to evoke emotional responses.

5. A method as in claim 1, wherein said step of applying light stimulus or images to the subject'"'"'s eyes include showing the subject dynamic images to evoke emotional responses.

6. A method as in claim 1, wherein said step of giving a neuropsychological and cognition battery of tasks to the subject includes testing of the subject'"'"'s memory, attention, and/or executive function.

7. A method as in claim 1, further comprising recording the subject'"'"'s speech in response to verbal tasks and performing language processing of the recorded speech.

8. A method as in claim 1, further comprising measuring heart rate variability of the subject during said battery of tasks.

9. A system used to diagnose Autism and/or Autism Spectrum Disorder (ASD) of a subject, comprising:

an EEG measurement device that measures brain wave patterns of the subject while performing a series of tasks to establish a baseline brain wave pattern;

a device adapted to apply a light stimulus or images to the subject'"'"'s eyes and to capture eye movements and/or changes in facial expression in response to the light stimulus or images;

an auditory testing device that tests the subject'"'"'s sensitivity to sound and records the subject'"'"'s speech in response to verbal tasks; and

a processing device that performs language processing of the recorded speech and correlates the baseline brain wave pattern, eye movements and/or facial expression, and processed language to a profile data indicative of Autism and/or ASD.

10. A system as in claim 9, wherein the device adapted to apply a light stimulus or images to the subject'"'"'s eyes and to capture eye movements and/or changes in facial expression in response to the light stimulus or images comprises an eye tracking camera that tracks the subjects eye movements and/or tracks changes in facial expression of the subject in response to light stimulus or images.

11. A system as in claim 9, wherein the device adapted to apply a light stimulus or images to the subject'"'"'s eyes and to capture eye movements and/or changes in facial expression in response to the light stimulus or images comprises biosensors that track eye gaze position and duration and pupillary response.

12. A system as in claim 9, further comprising static probes that measure parts of the subject'"'"'s face.

13. A system as in claim 9, further comprising dynamic probes that apply dynamic stimulus to the subject relating to an emotionally evocative event and measure the subject'"'"'s response to the dynamic stimulus.

14. A system as in claim 9, further comprising a biosensor adapted to measure the subject'"'"'s heart rate variability during a neuropsychological and cognition battery of tasks given to the subject.