PYRROLOBENZODIAZEPINE ANTIBODY DRUG CONJUGATES AND METHODS OF USE
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Abstract
The invention provides antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug moiety via a disulfide linker, pyrrolobenzodiazepine linker-drug intermediates, and methods of using the antibody-drug conjugates.
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44 Claims
- 1. An antibody-drug conjugate compound of Formula II:
- 19. An antibody-drug conjugate compound of Formula II:
- 41. An antibody drug conjugate, or a pharmaceutically acceptable salt thereof, of Formula IIf
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