SYSTEM AND METHOD FOR ADJUSTING INSULIN DELIVERY

• US 20180200438A1
• Filed: 01/12/2018
• Published: 07/19/2018
• Est. Priority Date: 01/13/2017
• Status: Active Grant

• Current Assignee: Insulet Corporation
• Original Assignee: Bigfoot Biomedical, Inc.
• Inventors: Mazlish, Bryan, Desborough, Lane, Naylor, Ross
• Granted Patent: US 10,583,250 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61K 38/28 Insulins
• CPC Class Codes: A61M 2205/3379 Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 2205/35 Communication
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/003 Kits for diabetics
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61M 5/31568 Means keeping track of the total dose administered, e.g. since the cartridge was inserted
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/63 for local operation

Abstract

The embodiments described herein may relate to methods and systems for adjusting insulin delivery. Some methods and systems may be configured to adjust insulin delivery to personalize automated insulin delivery for a person with diabetes. Such personalization may include adjusting user specific dosage parameters in response to one or more back-filled time segments associated with a diurnal time block.

Claims

1. A method comprising:

determining available insulin delivery segments for a back-fill time based on a correction bolus;

determining a cumulative insulin on board (IOB) based on all the available insulin delivery segments being back-filled;

back-filling a number of the available insulin delivery segments;

adjusting the number of the available insulin delivery segments that are back-filled until one of the cumulative IOB based on the number of back-filled insulin delivery segments is equal to or less than the correction bolus, or the cumulative insulin of the number of back-filled insulin delivery segments is less than the correction bolus; and

adjusting a baseline basal rate based on the back-filled insulin delivery segments, the baseline basal rate used for a diurnal time block related to at least a portion of the back-fill time.

2. The method of claim 1, wherein the correction bolus is a negative bolus.

3. The method of claim 1, further comprising configuring an insulin delivery system to deliver insulin during the diurnal time block based on the adjusted baseline basal rate.

4. The method of claim 3, further comprising delivering insulin during the diurnal time block based on the adjusted baseline basal rate.

5. The method of claim 1, wherein the diurnal time block is for a same time of day that covers the portion of the back-fill time on a day later than when the correction bolus is delivered.

6. The method of claim 1, further comprising adjusting one or both of a carbohydrate-to-insulin ratio and an insulin sensitivity factor for the diurnal time block.

7. The method of claim 1, wherein back-filling the number of available insulin delivery segments comprises adjusting at least one insulin delivery action associated with each of the number of available insulin delivery segments.

8. The method of claim 7, wherein the at least one insulin delivery action comprises delivering a dose of insulin that is a multiple or a fraction of a baseline basal insulin.

9. The method of claim 8, further comprising updating historical insulin delivery information based on one or more insulin delivery actions associated with the adjusted number of available insulin delivery segments.

10. A system comprising:

an insulin delivery device configured to deliver insulin via a plurality of insulin delivery actions over a back-fill time prior to a correction bolus, and deliver the correction bolus; and

a control device in communication with the insulin delivery device, the control device configured to;

obtain an amount of insulin delivered in the correction bolus;

determine available insulin delivery segments for the back-fill time based on which of the plurality of insulin delivery actions delivered less than a maximum amount of insulin relative to a baseline basal rate;

back-fill a number of the available insulin delivery segments based on an amount of insulin in the correction bolus; and

adjust a baseline basal rate based on the back-filled insulin delivery segments, the baseline basal rate used for a diurnal time block related to at least a portion of the back-fill time.

11. The system of claim 10, wherein the insulin delivery device delivers insulin during the diurnal time block based on the adjusted baseline basal rate.

12. The system of claim 10, further comprising a user interface, wherein the user interface is configured to display historical insulin delivery information.

13. The system of claim 12, wherein the user interface is configured to update displayed historical insulin delivery information based on one or more insulin delivery actions associated with the number of available insulin delivery segments.

14. The system of claim 13, wherein at least one of the one or more insulin delivery actions is associated with delivering a dose of insulin that is a multiple or a fraction of baseline basal insulin.

15. The system of claim 10, further comprising personalizing the delivery of insulin for a diurnal time period by adjusting one or both of a carbohydrate-to-insulin ratio and an insulin sensitivity factor for the diurnal time block,

wherein the personalizing is completed after delivering the correction bolus.