METHODS AND COMPOSITIONS FOR STIMULATING BENEFICIAL BACTERIA IN THE GASTROINTESTINAL TRACT

• US 20180207165A1
• Filed: 03/09/2018
• Published: 07/26/2018
• Est. Priority Date: 11/01/2012
• Status: Abandoned Application

• Current Assignee: Academisch Ziekenhuis Groningen, Rijksuniversiteit Groningen
• Original Assignee: Academisch Ziekenhuis Groningen, Rijksuniversiteit Groningen
• Inventors: Harmsen, Hermanus Josef Martinus, Khan, Muhammad Tanweer, Sadaghian Sadabad, Mehdi, Van Dijl, Jan Maarten
• Application Number:
  US15/916,704
• Publication Number:
  US 20180207165A1
• Time in Patent Office: Days
• CPC Class Codes: A23L 33/135 Bacteria or derivatives thereof, e.g. probiotics
• CPC Class Codes: A23L 33/15 Vitamins
• CPC Class Codes: A23L 33/21 Addition of substantially indigestible substances, e.g. dietary fibres
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/3202 Prebiotics, ingredients fermented in the gastrointestinal tract by beneficial microflora
• CPC Class Codes: A23V 2200/3204 Probiotics, living bacteria to be ingested for action in the digestive tract
• CPC Class Codes: A23V 2250/5062 Inulin
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/525 Isoalloxazines, e.g. riboflavins, vitamin B2
• CPC Class Codes: A61K 31/675 having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• CPC Class Codes: A61K 31/733 Fructosans, e.g. inulin
• CPC Class Codes: A61K 35/66 Microorganisms or materials therefrom fungi, yeasts or candida A61K36/06
• CPC Class Codes: A61K 35/74 Bacteria therapeutic use of a bacterial protein A61K38/00
• CPC Class Codes: A61K 35/741 Probiotics probiotic yeast, e.g. saccharomyces A61K36/06
• CPC Class Codes: A61K 9/1623 Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
• CPC Class Codes: A61K 9/1652 Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin homeopathic globules A61K9/1623
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The invention relates to supporting the growth or maintenance of oxygen-sensitive bacteria in the gastrointestinal tract of an animal. Provided is the use of riboflavin, riboflavin phosphate or a salt thereof, for the manufacture of a food composition, pharmaceutical composition, food or dietary supplement, for the selective stimulation of Faecalibacterium prausnitzii in the gastrointestinal tract. Also provided is a synbiotic composition comprising living beneficial butyrate-producing anaerobic bacteria formulated with riboflavin, riboflavin phosphate or a salt thereof, and cysteine.

Claims

1-16. -16. (canceled)

17. A method for the selective stimulation of Faecaliumbacterium prausnitzii in the gastrointestinal tract in an animal, comprising administering to the animal riboflavin, riboflavin phosphate or a physiologically acceptable salt thereof, in an amount effective to selectively stimulate the growth of Faecaliumbacterium prausnitzii in the gastrointestinal tract.

18. The method according to claim 17, wherein the animal is a human, pet or livestock.

19. The method according to claim 17, wherein the riboflavin, riboflavin phosphate or physiologically acceptable salt thereof is used in an amount of 0.1 to 1000 mg per kg of body weight per day.

20. The method according to claim 17, wherein the riboflavin, riboflavin phosphate or physiologically acceptable salt thereof is used in an amount of 1-100 mg per kg of body weight per day.

21. The method according to claim 17, wherein riboflavin is used for at least 3 consecutive days.

22. The method according to claim 17, wherein riboflavin is used for at least 7 consecutive days.

27. The method according to claim 17, wherein riboflavin is used for at least 10 consecutive days.

23. A method for preventing, treating or reducing the symptoms associated with an inflammatory gastrointestinal disorder, comprising administering to a human subject in need thereof an amount of riboflavin effective to maintain, support or stimulate the growth of Faecaliumbacterium prausnitzii in the gastrointestinal tract.

24. The method according to claim 23, wherein the inflammatory gastrointestinal disorders are inflammatory bowel diseases.

25. The method according to claim 24, wherein the inflammatory bowel diseases are Crohn'"'"'s disease and ulcerative colitis.

26. The method according to claim 23, wherein the riboflavin, riboflavin phosphate or physiologically acceptable salt thereof is used in an amount of 0.1-1000 mg per kg of body weight per day.

27-1. The method according to claim 23, wherein the riboflavin, riboflavin phosphate or physiologically acceptable salt thereof is used in an amount of 1-100 mg per kg of body weight per day.

28. The method according to claim 23, wherein riboflavin is used for at least 3 consecutive days.

29. The method according to claim 23, wherein riboflavin is used for at least 7 consecutive days.

30. The method according to claim 23, wherein riboflavin is used for at least 10 consecutive days.