THERAPEUTIC USES OF PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES
First Claim
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1. A method of treating a bacterial infection in a subject comprising administering to the subject an effective amount of a compound of Formula (I) in combination with an additional medicament, wherein Formula (I) has the structure:
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Abstract
Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
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30 Claims
- 1. A method of treating a bacterial infection in a subject comprising administering to the subject an effective amount of a compound of Formula (I) in combination with an additional medicament, wherein Formula (I) has the structure:
- 23. A method of treating a bacterial infection in a subject comprising administering to the subject an effective amount of a compound in combination with meropenem, wherein the compound has the structure:
- 29. A method of treating a bacterial infection in a human subject comprising administering an effective amount of a pharmaceutical composition to the subject, the pharmaceutical composition comprising a compound, meropenem, sodium carbonate and saline, wherein the administration is intravenous, wherein the compound has the structure:
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