NUTRITIONAL COMPOSITIONS AND INFANT FORMULAS COMPRISING BIFIDOBACTERIUM ANIMALIS SSP. LACTIS AND OPTIONALLY A MIX OF OLIGOSACCHARIDES FOR INDUCING A GUT MICROBIOTA CLOSE TO THE ONE OF BREAST FED INFANTS

• US 20180220691A1
• Filed: 08/04/2016
• Published: 08/09/2018
• Est. Priority Date: 08/04/2015
• Status: Active Application

• Current Assignee: Societe des Produits Nestle SA (Nestle SA)
• Original Assignee: Nestec SA (Nestle SA)
• Inventors: Garcia-Rodenas, Clara Lucia, Berger, Bernard, Rezzonico, Enea
• Application Number:
  US15/749,536
• Publication Number:
  US 20180220691A1
• Time in Patent Office: Days
• CPC Class Codes: A23L 33/135 Bacteria or derivatives thereof, e.g. probiotics
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/1946 Short-chain triglycerides
• CPC Class Codes: A23V 2250/282 Oligosaccharides, digestible
• CPC Class Codes: A23V 2400/531 Lactis
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/702 Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• CPC Class Codes: A61K 35/745 Bifidobacteria
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The invention relates to a nutrition composition with promoting or inducing a gut microbiota that is closer to infants fed exclusively with human breast milk, in comparison to infant fed with conventional nutritional composition. The composition is in particular intended for infants between 0 and 12 months of age fed predominantly with infant formula. The infants can be fed during 2, 4, or 6 months and the composition can be an infant formula. The composition promotes a healthy intestinal flora and has beneficial long and short terms effects.

Claims

1. A method for promoting or inducing a gut microbiota that is closer to the microbiota of infants fed exclusively with human breast milk, in comparison to the microbiota of infants fed predominantly with a conventional nutritional composition not comprising the probiotic, in infants or young children between 0 and 36 months comprising administering a nutritional composition to such infants or young children comprising a Bifidobacterium animalis spp. lactis probiotic.

2. The method of claim 1 wherein the composition comprises at least one component selected from the group consisting of N-acetylated oligosaccharide, galacto-oligosaccharide, and sialylated oligosaccharide.

3. The method of claim 1 wherein the infants are born with a fragile or unbalanced microbiota or dysbiosis of microbiota.

4. The method of claim 1 wherein the infants are 0 to 6 months old.

5. The method of claim 1 wherein the composition comprises oligofructose.

6. The method of claim 1 wherein the composition comprising fat and at least 8% of the fat is sn2 palmitate.

7. The method of claim 1 wherein the composition comprises triglycerides having more than 33% of the palmitic acid in sn2 position.

8. The method of claim 1 wherein the composition is an infant formula or a follow-on formula.

9. The method of claim 1 wherein the composition comprises alpha-lactalbumin proteins in an amount of at least 0.3 g/100 kcal of composition.

10. The method of claim 1 wherein the promoting or inducing a gut microbiota that is closer to infants fed exclusively with human breast milk further comprises an up-regulation of the population of B. animalis and/or Bifidobacterium, and/or B. Longum and/or Lactobacillus, and/or a down regulation of the populations of Coprobacillus and/or Streptococcus.

11. The method of claim 1 wherein the promoting or inducing a gut microbiota that is closer to the microbiota of infants fed exclusively with human breast milk comprises promoting or inducing a gut microflora that has a phylogenetic distance to the microbiota of breast fed infants of less than 0.3 units (measured by Unifrac method).

12. The method of claim 1 wherein the promoting and/or inducing a gut microbiota that is closer to infants fed exclusively with human breast milk is measurable in infants stools.

13. The method of claim 1 wherein the composition is fed or intended to be fed during the first 12 weeks of life.

14. The method of claim 1 wherein the promoting and/or inducing a gut microbiota that is closer to infants fed exclusively with human breast milk comprises promoting and/or inducing a healthy growth, a healthy immune system and/or a healthy gut function, especially later in life.

15. The method of claim 1 wherein the probiotic Bifidobacterium animalis spp. lactis is CNCM I-3446.

16. The method of claim 1 wherein the probiotic is present in the composition in an amount of between 10⁵ and 10¹² cfu per gram of composition.