HUMANIZED ANTIBODIES
First Claim
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1. A humanized antibody or binding fragment thereof comprising an ultralong CDR3.
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Abstract
The present disclosure provides humanized antibodies, including antibodies comprising an ultralong CDR3 and uses thereof.
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Citations
176 Claims
- 1. A humanized antibody or binding fragment thereof comprising an ultralong CDR3.
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3. (canceled)
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71. A library of humanized antibodies or binding fragments thereof, wherein the antibodies or binding fragments thereof comprise an ultralong CDR3.
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72-141. -141. (canceled)
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142. A CDR3 scaffold comprising a X1X2X3X4X5 motif,
wherein X1 is threonine (T), glycine (G), alanine (A), serine (S), or valine (V), wherein X2 is serine (S), threonine (T), proline (P), isoleucine (I), alanine (A), valine (V), or asparagine (N), wherein X3 is valine (V), alanine (A), threonine (T), or aspartic acid (D), wherein X4 is histidine (H), threonine (T), arginine (R), tyrosine (Y), phenylalanine (F), or leucine (L), and wherein X5 is glutamine (Q).
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143-179. -179. (canceled)
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176-179. -179. (canceled)
Specification