METHOD OF TREATING PAIN WITH AN ANTIBODY AGAINST NETRIN-4, UNC5B OR NEOGENIN
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Abstract
The present invention provides a screening method for pain suppressors, which method is characterized by using netrin-4 and/or a netrin-4 receptor to select a substance capable of inhibiting downstream signaling from netrin-4. According to the screening method of the present invention, pain suppressors useful as a preventive or therapeutic medicine for pain can be identified. The present invention also provides a pharmaceutical composition for prevention or treatment of pain, which composition comprises, as an active ingredient, a substance capable of inhibiting downstream signaling from netrin-4.
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Citations
21 Claims
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1-14. -14. (canceled)
- 15. A screening method for pain suppressors, characterized by using netrin-4 and/or a netrin-4 receptor to select a substance capable of inhibiting downstream signaling from netrin-4, the netrin-4 receptor being Unc5B or neogenin.
- 20. A method for prevention or treatment of pain, comprising the step of administering, to a mammal, an effective amount of a nucleic acid capable of inhibiting the expression of netrin-4, Unc5B or neogenin.
Specification