HERBO-MINERAL FORMULATION FOR PREVENTION, TREATMENT AND MANAGEMENT OF DIABETES AND METHOD OF PREPARATION THEREOF

• US 20180236018A1
• Filed: 04/23/2018
• Published: 08/23/2018
• Est. Priority Date: 04/24/2017
• Status: Active Grant

• Current Assignee: Muniyal Ayurvedic Research Centre
• Original Assignee: Muniyal Ayurvedic Research Centre
• Inventors: SHETTY, M Vijayabhanu
• Granted Patent: US 10,639,341 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 35/614 Cnidaria, e.g. sea anemones, corals, coral animals or jellyfish
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/24 Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
• CPC Class Codes: A61K 36/328 Commiphora, e.g. mecca myrrh or balm of Gilead
• CPC Class Codes: A61K 36/37 Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
• CPC Class Codes: A61K 36/59 Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
• CPC Class Codes: A61K 36/61 Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
• CPC Class Codes: A61K 36/67 Piperaceae (Pepper family), e.g. Jamaican pepper or kava
• CPC Class Codes: A61K 36/9066 Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
• CPC Class Codes: A61K 36/9068 Zingiber, e.g. garden ginger
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics

Abstract

Herbo-mineral formulation for prevention, treatment and management of Diabetes and method of preparing the same are disclosed herein. The disclosed herbo-mineral formulation includes herb and mineral elements which facilitate in treating Diabetes and Diabetes associated complications. Further the disclosed formulation has been observed to exhibit hypoglycemic, hypolipidemic, and pancreatic cell regenerative properties.

Claims

1. A formulation for treatment and management of Diabetes and related complications comprising:

a herb element comprising of Salacia chinensis, Gymnema sylvestre, Emblica officinalis, Eugenia jambolana, Curcuma longa, Commiphora mukul (Guggulu) and Tinospora cordifolia or their extracts thereof; and

a mineral element comprising of shilajit and bhasma.

2. The formulation as claimed in claim 1 wherein said herb element further comprises atleast one herb selected from a group consisting of Withania somnifera, Terminalia chebula, Terminalia bellerica, Andrographis paniculata, Boerhavia diffusa, Azhadirachta indica, Aristolochia indica, Aegle marmelos, Cyperus rotundus, Hemedesmus indicus, Trichosanthes dioica, Santalum alba, Terminalia arjuna, Woodfordia fruiticosa, Glycerrhiza glabra, Mucuna pruriens, Myrica nagi, Plumbago rosea, Inula racemosa, Zingiber officinalis, Piper longum and Piper nigrumor their extracts thereof.

3. The formulation as claimed in claim 1, wherein said mineral element comprises of atleast one bhasma selected from a group consisting of Abhraka Bhasma, Vanga Bhasma, Yashada Bhasma, Pravala Bhasma, Loha Bhasma and Swarna Makshika Bhasma.

4. The formulation as claimed in claim 1, wherein Salacia chinensis is present in an amount ranging from 4 to 8 wt %, Gymnema sylvestre is present in an amount ranging from 4 to 8 wt %, Emblica officinalis is present in an amount ranging from 2 to 6 wt %, Eugenia jambolana is present in an amount ranging from 4 to 8 wt %, Curcuma longa is present in an amount ranging from 3 to 7 wt %, Commiphora mukul (Guggulu) is present in an amount ranging from 3 to 7 wt % and Tinospora cordifolia is present in an amount ranging from 3 to 7 wt %.

5. The formulation as claimed in claim 1, wherein shilajit is present in an amount ranging from 2 to 6 wt %.

6. The formulation as claimed in claim 3, wherein concentration of Abhraka Bhasma is about 2 wt %, concentration of Vanga Bhasmais about 1 wt %, concentration of Yashada Bhasma is about 1 wt %, concentration of Pravala Bhasma is about 2 wt %, concentration of Loha Bhasma is about 2 wt % and concentration of Swarna Makshika Bhasma is about 2 wt %.

7. The formulation as claimed in claim 1, further comprising a suitable excipient, preferably gum acacia.

8. The formulation as claimed in claim 1, further comprising one or more additives selected from the group consisting of a flavor, a colorant, a preservative, and a pH adjuster.

9. The formulation as claimed in claim 1, wherein said formulation is administered in a form selected from a group consisting of powder, emulsion, tablets, capsules, troches and pills

10. The formulation as claimed in claim 1, wherein said formulation is prepared in the form of a tablet.

11. The formulation as claimed in claim 10, wherein said tablet is in the form of 500 mg tablets.

12. Use of formulation as claimed in claim 1 in the preparation of a medicament for treatment of a condition selected from a group consisting of diabetes, hyperglycemia, low glucose tolerance, hyperinsulinemia and related complications.

13. A process for the preparation of formulation as claimed in claim 1, comprising:

levigating bhasmas, Guggulu and shilajit;

adding finely powdered herbs; and

adding grinding decoction while continuing grinding to obtain a ground mass.

14. The process for the preparation of formulation as claimed in claim 13, wherein said bhasmas are selected from a group consisting of Abhraka Bhasma, Vanga Bhasma, Yashada Bhasma, Pravala Bhasma, Loha Bhasma and Swarna Makshika Bhasma.

15. The process for the preparation of formulation as claimed in claim 13, wherein said finely powdered herbs comprises of finely powdered form of atleast one herb selected from a group consisting of dried root of Salacia chinensis, dried root of Withania somnifera, dried root of Boerhavia diffusa, dried root of Aristolochia indica, dried root of Aegle marmelos, dried root of Cyperus rotundus, dried root of Hemedesmus indicus, dried root of Glycerrhiza glabra, dried root of Inula racemosa, dried root of Plumbago rosea, dried fruits of Terminalia chebula, dried fruits of Terminalia bellerica, dried fruits of Emblica officinalis, dried fruits of Piper longum and dried fruits of Piper nigrum, dried bark of Azhadirachta indica, dried bark of Myrica nagi, dried bark of Terminalia arjuna, dried plant of Andrographis paniculata, dried plant of Trichosanthes dioica, dried leaves of Gymnema sylvestre, dried heartwood of Santalum alba, dried flowers of Woodfordia fruiticosa, dried seeds of Mucuna pruriens, dried seeds of Eugenia jambolana, dried rhizome of Curcuma longa, dried rhizome of Zingiber officinalis and dried stem of Tinospora cordifolia.

16. The process for the preparation of formulation claimed in claim 13, wherein said grinding decoction is a decoction of at least one herb selected from the group consisting of Salacia chinensis, Cedrus deodara, Tribulus terrestris, Acacia catechu, Andrographis paniculata, Pterocarpus marsupium, Ocimium sanctum, Adhatoda vasica, Aegle marmelos, Carum carvi, Trigonella foenum graecum, Momordia charantia and Araca catechu.

17. A method of treating diabetes and associated complications comprising administering a therapeutically effective amount of the formulation claimed in claim 1.

18. The method of treating Diabetes and associated complications as claimed in claim 17, wherein said therapeutically effective amount is 500 to 1000 mg administered one to three times a day.

19. The method as claimed in claim 17 wherein said formulation is administered along with administration of at least one other medication prescribed for treatment of Diabetes and associated complications.